Mechanisms of Rejuvenation and Age-Acceleration in Heterochronic Blood Exchange (R01 Clinical Trial Not Allowed)

Funding Agency:
National Institutes of Health

This FOA will support research on aspects of rejuvenation and accelerated aging observed specifically in heterochronic blood exchange (HBE) experiments. The objectives are to identify the multiple factors involved, the multiple cell types involved, and the mechanisms underlying rejuvenation or accelerated aging that is observed in the transfer of phenotypes between young and old laboratory animals. It is also anticipated that molecular signatures of rejuvenation or accelerated aging will be obtained from research supported under this FOA.


  • Letter of Intent Due Date(s): May 17, 2020
  • Application Due Date(s): June 17, 2020

RFA-AG-21-002 Expiration Date June 18, 2020

Agency Website



Amount Description

Application budgets are limited to $300,000 in direct costs per year.

The maximum project period is five years.

    Funding Type





    Environmental & Life Sciences
    Medical - Basic Science

    External Deadline

    June 17, 2020