Mechanistic Studies on Social Behavior in Substance Use Disorder (R01 Clinical Trial Optional)

Funding Agency:
National Institutes of Health

The purpose of this notice of funding opportunity (NOFO) is to solicit applications proposing mechanistic, transdisciplinary research on social behavior and its relationships with the onset, trajectory, and impact of Substance Use Disorders (SUDs) and comorbidities.

This NOFO is intended to support basic or early translational studies that may, but need not, be considered NIH clinical trials; this may include mechanistic clinical trials, observational studies, or secondary analysis of human data. This NOFO is not intended to support studies designed to test the safety or demonstrate the efficacy of an intervention, or studies in animal models.

Applications in which all the research meets the criteria for Basic Experimental Studies involving Humans (BESH) should be submitted under the companion NOFO, RFA-DA-25-033. Studies involving animals should be submitted under the companion ‘Clinical Trials Not Allowed’ NOFO, RFA-DA-25-034.

This NOFO requires a Plan for Enhancing Diverse Perspectives (PEDP), which will be assessed as part of the scientific and technical peer review evaluation. Applications that fail to include a PEDP will be considered incomplete and will be withdrawn. Applicants are strongly encouraged to read the NOFO instructions carefully and view the available PEDP guidance material.


  • Letter of Intent Due Date(s): July 14, 2024

  • Application Due Date: August 14, 2024

RFA-DA-25-032 Expiration Date August 15, 2024




Medical - Clinical Science
Social Sciences

External Deadline

August 14, 2024