Mechanistic Studies on Social Behavior in Substance Use Disorder (R01 Clinical Trials Not Allowed)

Funding Agency:
National Institutes of Health

The purpose of this notice of funding opportunity (NOFO) is to solicit applications proposing mechanistic transdisciplinary research in animal models that integrates approaches across social/cognitive neuroscience with perspectives from fields with complementary approaches to the study of social behavior, with the goal of developing a testable conceptual or computational model that provides mechanistic insights into social behavior and its relationships with the onset, trajectory and impact of Substance Use Disorders (SUDs) and comorbidities. 

This NOFO is intended to support basic or translational research in non-human animal models, including secondary analysis of data from research in animal models. Applications including studies involving human subjects should submit under one of the companion NOFOs. Applications with observational research in humans, secondary analysis of human subjects data, or research specifically aimed at studying disease processes or evaluating clinical interventions should submit under the companion Clinical Trials Optional NOFO, RFA-DA-25-032. Applications proposing Basic Experimental Studies involving Humans should be submitted under the companion “Basic Experimental Studies with Humans (BESH) Required” NOFO, RFA-DA-25-033

This NOFO requires a Plan for Enhancing Diverse Perspectives (PEDP), which will be assessed as part of the scientific and technical peer review evaluation. Applications that fail to include a PEDP will be considered incomplete and will be withdrawn. Applicants are strongly encouraged to read the NOFO instructions carefully and view the available PEDP guidance material.


  • Letter of Intent Due Date(s): July 14, 2024

  • Application Due Date: August 14, 2024

RFA-DA-25-034 Expiration Date August 15, 2024

Agency Website



Amount Description

Direct costs are limited to $425,000 and need to reflect the actual needs of the proposed project.  

The award project period must be appropriate for the scope of the proposed research and cannot exceed 5 years. 

Funding Type





Medical - Clinical Science
Social Sciences

External Deadline

August 14, 2024