Medical Technology Enterprise Consortium (MTEC) -- Volumetric muscle loss (VML) repair following extremity trauma

Funding Agency:
Department of the Army


The Medical Technology Enterprise Consortium (MTEC) is excited to post this announcement for a Request for Project Proposals (RPP) entitled, “Volumetric muscle loss (VML) repair following extremity trauma.” The goal of this research is to develop an off-the-shelf biologic prototype capable of preventing, mitigating or treating traumatic large-volume muscle loss (VML) injuries of the extremities.  While such injuries are devastating, irreversible, and uniformly associated with long term disability, recent advances in regenerative medicine have made new approaches possible.  The Government seeks to assess the potential for repurposing products already commercially available or in clinical development for related indications, such as critical limb ischemia, iatrogenic muscle injuries, Duchene’s muscular dystrophy, compartment syndrome, and severe sports medicine injuries.  Products capable of regenerating or repairing multiple tissue types or creating a therapeutic wound environment will also be considered.

The focus of this RPP is to develop an advanced prototype of an off-the-shelf biologic capable of preventing, mitigating or treating traumatic large-volume muscle loss (VML) injuries along the continuum of care.  The prototype must be able to repair injured muscle tissue to a degree suitable for extremity repair and reconstruction.

Full proposals are due no later than November 13, 2018 at 12:00pm EST.

Agency Website

Eligibility Requirements

Offerors must be MTEC Members in good standing.



Amount Description

The U.S. Government (USG) currently has available approximately $2 million (M) for Fiscal Years (FY), FY18, FY19, and FY20 to fund Phase 1. It is possible that additional funds of at least $2.5M for FY21 and FY22 may become available for the continuation of this project through Phase 2.

MTEC anticipates that a single award will be made. 

The Period of Performance (POP) is 24 months for Phase 1, and an additional 36 months for Phase 2 if milestones/deliverables are achieved in Phase 1.

Funding Type





Engineering and Physical Sciences
Environmental & Life Sciences
Medical - Basic Science
Medical - Clinical Science
Medical - Translational

External Deadline

November 13, 2018