Sponsor Deadline
Posted: 10/20/2023

Microphysiological Systems to Advance Precision Medicine for AD/ADRD Treatment and Prevention (U54 Clinical Trial Not Allowed)

This Notice of Funding Opportunity (NOFO) invites U54 Cooperative Agreement applications aiming to establish multi-component Alzheimer’s Disease (AD) and AD-Related Dementias (ADRD) Translational Centers for Microphysiological Systems (MPS) (AD/ADRD MPS Translational Centers). The overarching purpose of this Centers program is to develop 2D and 3D models of AD/ADRD as reproducible and scalable platforms that recapitulate key features of human AD/ADRD pathophysiology to be used as precision medicine research tools to investigate the complex biology of AD/ADRD and to accelerate multiple aspects of drug discovery and preclinical drug development. 


  • Letter of Intent Due Date(s): January 15, 2024

  • Application Due Date: February 15, 2024

RFA-AG-24-040 Expiration Date February 16, 2024

Amount Description

An application may request a budget of up to $2.5 million direct costs per year. Budgets should reflect the actual needs of the proposed project.

An application may request a project period up to five years.

Funding Type