Modulating Intestinal Microbiota to Enhance Protective Immune Responses against Cancer (R01 Clinical Trial Not Allowed)

Funding Agency:
National Institutes of Health

 The purpose of this Funding Opportunity Announcement (FOA) is to support research which can elucidate mechanism(s) of action by which gut microbes inhibit or enhance anti-tumor immune responses.  Thus, research projects should be focused on delineating how specific microbes or their metabolites target host immune responses to prevent colitis-associated or sporadic tumor formation.  

This FOA runs in parallel with an FOA of identical scientific scope, PAR-19-199, which utilizes the Exploratory/Developmental Grant (R21) mechanism.


  • Letter of Intent Due Date(s): 30 days prior to the application due date
  • Application Due Date(s): June 10, 2019; November 6, 2019; June 10, 2020; November 6 2020; June 10, 2021; November 8, 2021

PAR-19-198 Expiration Date November 9, 2021




Medical - Basic Science

External Deadline

June 10, 2020