Molecular Transducers of Physical Activity Clinical Centers (U01)

Funding Agency:
National Institutes of Health

The purpose of this FOA is to invite applications for Clinical Centers to conduct a multi-center clinical study as part of the Molecular Transducers of Physical Activity Consortium (MoTrPAC;http://commonfund.nih.gov/MolecularTransducers). Investigators will collect biospecimens for analysis using genomics, transcriptomics, epigenomics, metabolomics, and proteomics for the discovery of the entire range of molecular transducers that underlie the effects of physical activity in humans.

Six companion FOAs will establish the elements of the MoTrPAC. Clinical Centers will collect tissues such as blood, muscle, and fat from well-characterized participants engaging in physical activity. Biospecimens will be analyzed by Genomics, Epigenomics, and Transcriptomics Chemical Analysis Sites and Metabolomics and Proteomics Chemical Analysis Sites. Preclinical Animal Studies Sites (PASS) will provide additional tissues that cannot be obtained from human subjects and allow for further characterization and validation of molecular transducers identified from the chemical analysis of human samples. A Bioinformatics Center will oversee data standardization, integration, and storage and will implement data sharing and computational tools for the integrated analysis of clinical and molecular data. Overall coordination will be provided by a Consortium Coordination Center (CCC).

Awardees will comprise the MoTrPAC and must work collaboratively to plan and execute a large study to discover and characterize the molecular transducers (the 'molecular map') that underlie the beneficial effects of physical activity in humans. The product will be a publically available data resource that will enhance and accelerate subsequent mechanistic research on diseases and conditions affected by physical activity. 

Companion FOAs:

RFA-RM-15-010, U24 Resource-Related Research Projects--Cooperative Agreements 
RFA-RM-15-011, U24 Resource-Related Research Projects--Cooperative Agreements
RFA-RM-15-012, U24 Resource-Related Research Projects--Cooperative Agreements
RFA-RM-15-013, U01 Research Project--Cooperative Agreements
RFA-RM-15-014, U24 Resource-Related Research Projects--Cooperative Agreements

Deadlines:

  • Letter of Intent Due Date(s): February 18, 2016
  • Application Due Date(s): March 18, 2016, by 5:00 PM local time of applicant organization.

​RFA-RM-15-015 Expiration Date March 19, 2016

Agency Website

Amount

$5,500,000

Amount Description

Application budgets are limited to $100,000 direct costs for the first year. Adult Clinical Center application budgets are limited to $1,000,000 direct costs in each of years 2 through 5, and to $400,000 direct costs in year 6. Pediatric Clinical Center application budgets are limited to $600,000 direct costs for each of years 2 through 5, and to $250,000 direct costs in year 6. Budgets should reflect the actual needs of the proposed project.

Funding Type

Grant

Eligibility

Faculty
Institutional

Category

Medical
Medical - Basic Science
Medical - Clinical Science

External Deadline

March 18, 2016