Multi-disciplinary Machine-assisted, Genomic Analysis and Clinical Approaches to Shortening the Rare Diseases Diagnostic Odyssey (UG3/UH3 Clinical Trial Optional)

Funding Agency:
National Institutes of Health

This Funding Opportunity Announcement (FOA) invites researchers to submit applications for multi-disciplinary diagnostic strategies for rare diseases that combine machine-assistance, genomic analysis, and clinical consultation. Of particular importance, these strategies must be able to be adopted and performed at the primary or secondary care levels by front-line healthcare providers and be readily integrated into their clinical care workflow.


  • Letter of Intent Due Date(s): 30 days prior to the application due date

  • Application Due Date(s): April 19, 2021

RFA-TR-21-008 Expiration Date April 20, 2021

Agency Website

Eligibility Requirements

In view of the goals of this FOA, applicants should assemble a multi-disciplinary team with expertise in medical informatics, genetic analysis, rare diseases, and front-line healthcare when preparing the application.

Amount Description


Direct cost funding support may not exceed $200,000 per year for the UG3 phase of awards and $300,000 per year for the UH3 phase awards.

Funding Type





Engineering and Physical Sciences
Medical - Basic Science
Medical - Clinical Science
Medical - Translational

External Deadline

April 19, 2021