NCI Cancer Screening Research Network: ACCrual, Enrollment, and Screening Sites (ACCESS) Hub (UG1 Clinical Trial Required)

Funding Agency:
National Institutes of Health

This Funding Opportunity Announcement (FOA) is one of three FOAs that will support a comprehensive effort by the National Cancer Institute (NCI) to provide infrastructure to develop the Cancer Screening Research Network (CSRN). The primary goal of the CSRN is the conduct of multi-center cancer screening trials and studies. This Network is designed to take advantage of large and diverse populations receiving routine care in a variety of healthcare settings. The CSRN will engage these populations in rigorous studies focused on cancer screening to improve early cancer detection and evaluate emerging cancer screening modalities with the ultimate goal of reducing cancer incidence, and cancer-related morbidity and mortality.

The CSRN will support the following components that will be individually awarded through the respective FOAs indicated below:

  • RFA-CA-23-020: CSRN Accrual, Enrollment, and Screening Site (ACCESS) Hubs (this FOA);
  • RFA-CA-23-021: CSRN Statistics and Data Management Center (SDMC); and
  • RFA-CA-23-022: CSRN Coordinating and Communication Center (CCC).

Each key component of the CSRN program is described briefly below:

  • CSRN ACCESS Hubs will establish multi-disciplinary teams to recruit participants to CSRN trials and studies, conduct the screening protocols, and participate in the scientific development and implementation of those trials and studies.
  • CSRN Statistics and Data Management Center (SDMC) will provide statistical expertise and centralized data management, quality control, and reporting in support of CSRN clinical trials and other cancer screening studies.
  • CSRN Coordinating and Communication Center (CCC) will provide cancer screening expertise and clinical trial leadership and is responsible for the coordination of all aspects of study operations, as well as the development and implementation of communication activities.

Only one application per institution is allowed.


  • Letter of Intent Due Date(s): January 28, 2023

  • Application Due Date:¬†February 28, 2023

RFA-CA-23-020 Expiration Date March 01, 2023

Agency Website

Eligibility Requirements

An eligible institution/organization for the purposes of this application is defined as a healthcare providing entity including, but not limited to, a consortium of academic and community institutions, a healthcare system, practice-based research network, or other institution providing direct medical care to patients that are considered one integral organizational entity under a single financial management system and governance structure.
Applicants that contain multiple types of eligible institutions are welcome to apply.



Amount Description

The requested budget must not exceed $750,000 in direct costs per year.

The maximum project period is 4 years.

Funding Type





Medical - Basic Science
Medical - Clinical Science
Medical - Translational

External Deadline

February 28, 2023