NCI -- Comprehensive Partnerships to Advance Cancer Health Equity (CPACHE) (Collaborative U54 Clinical Trial Optional)

Funding Agency:
National Institutes of Health

This funding opportunity seeks to support the Comprehensive Partnerships to Advance Cancer Health Equity (CPACHE) Program. The CPACHE Program develops and maintains comprehensive, long-term, and mutually beneficial partnerships between institutions serving underserved health disparity population and underrepresented students (ISUPSs) and NCI-designated Cancer Centers (CCs). The program aims to achieve a stronger national cancer program and address challenges in cancer and cancer disparities research, education and outreach, as well as their impact on underserved populations.

The institutions in each partnership are expected to work collaboratively to: 1) increase the cancer research and cancer research education capacity of the ISUPSs; 2) increase the number of students and investigators from underrepresented populations engaged in cancer research; 3) improve the effectiveness of CCs in developing and sustaining research programs focused on cancer health disparities and increase the number of investigators and students conducting cancer health disparities research; and 4) develop and implement cancer-related activities that benefit the surrounding underserved communities.


  • Letters of Intent Receipt Date(s): 45 days prior to the application due date
  • Application Receipt Dates(s): January 9, 2019; January 9, 2020, January 11, 2021

New Date January 12, 2021 per issuance of NOT-CA-20-007. (Original Expiration Date: January 10, 2020)

Agency Website

Eligibility Requirements

Each partnership must include both types of institutions: 1) institutions serving underserved health disparity population and underrepresented students (ISUPSs); and 2) NCI-designated Cancer Centers (CCs). Partnerships involving more than two institutions require NCI approval before submitting the application.

ISUPSs with medical schools, or with more focused education and research programs (e.g., Masters and PhD programs), as well as those that offer only baccalaureate degrees and Tribal Colleges may all participate in this initiative. 

This FOA supports linked applications. Multiple PDs/PIs are allowed on any single application. Because the FOA already supports a team approach between groups of experts across sites and collaborating applications, the designation of multiple PDs/PIs on a single application may be less likely to apply. PD(s)/PI(s) from each linked application should not be designated as multiple PDs/PIs on each application of a collaborative set.

For institutions/organizations proposing multiple PDs/PIs, visit the Multiple Program Director/Principal Investigator Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the SF424 (R&R) Application Guide.


    Specific to this FOA:

    • The PD(s)/PI(s) are preferred to be mid-to-senior-level scientists who have records of obtaining grants and will serve as role models and mentors to the partnership participants. However, a less experienced investigator at an ISUPS can be designated as one of multiple PDs/PIs, if there is an appropriate institutional investment in this investigator, and a demonstrable collaboration (active or planned) of the less experienced investigator with a more experienced PD/PI.
    • To underscore their commitment to the partnership, both contact PDs/PIs should also be reciprocally listed as PD(s)/PI(s) on the linked application from the partner institution.



    Amount Description

    Application budgets are limited to $2 million Direct Cost per year for partnerships of two institutions and $2.5 million Direct Cost per year for partnerships of three institutions. Applications with budget over these limits will not be accepted.

    The maximum period is 5 years. 

      Funding Type





      Curriculum Development
      Medical - Basic Science
      Medical - Clinical Science
      Medical - Translational

      External Deadline

      January 11, 2021