Network for Emergency Care Clinical Trials: Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN) - Clinical Coordinating Center (CCC) (U24)

Funding Agency:
National Institutes of Health

The purpose of this funding opportunity announcement (FOA) is to invite applications for the Clinical Coordinating Center (CCC) of Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN). SIREN will enable conduct of high-quality, multi-site clinical trials to improve the outcomes for patients with neurologic, cardiac, respiratory, hematologic and trauma emergency events. SIREN will consist of one Clinical Coordinating Center (CCC), one Data Coordinating Center (DCC) and up to 10 clinical centers (Hubs).  The CCC will facilitate implementation of clinical trials and will promote high quality and efficient timeliness in trial execution through such methods as master trial agreements and a central Institutional Review Board.  SIREN will implement a total of at least four large (>1,000 patient) simple, pragmatic clinical trials in the emergency department and pre-hospital settings. The clinical trials will be meritorious, peer–reviewed projects which will be awarded under separate funding announcements.

This FOA solicits applications for the Clinical Coordinating Center (CCC) for SIREN. Separate FOAs are issued to solicit applications for the clinical Hubs (RFA-NS-16-016) and the Data Coordinating Center (RFA-NS-16-015).   

Only one CCC application per institution is allowed.

Deadlines:

  • Duke Internal Deadline: April 18, 2016
  • Letter of Intent Due Date(s): 30 days prior to the application due date
  • Application Due Date(s): June 1, 2016

​RFA-NS-16-014 Expiration Date June 2, 2016

Agency Website

Eligibility Requirements

Investigators at the CCC institution may apply for a Hub award (RFA-NS-16-016). A CCC and a Hub at the same institution should be led by separate PDs/PIs to ensure that the CCC activities and the local Hub activities each receive full attention.

Awards for a CCC and a DCC will not be made to the same PD/PI or institution to ensure that data analyses are performed independently.

Amount

$2,340,000

Amount Description

Application budgets should not exceed a maximum of $680,000 direct costs for Year 1 or $415,000 direct costs/year for Years 2-5 of SIREN.

The maximum requested project period cannot exceed 5 years but the actual funded project period is dependent on reaching specific milestones as described in this FOA. 

Funding Type

Grant

Eligibility

Faculty
Institutional

Category

Interdisciplinary
Medical
Medical - Clinical Science

Internal Nomination

Owing to the sponsor's restriction on the number of applications that may be submitted from Duke, anyone wishing to pursue nomination should submit the following materials as one PDF.

* A letter of support from dean/chair - 1 to 1.5 pages
* Project summary - 2 to 4 pages
* NIH Biosketch

Applicants will need to submit internal materials through My Research Proposal. https://www.grantinterface.com/Common/LogOn.aspx?eqs=ApVvmgXCk2Uj7AzWyDEJKQ2

Instructions for setting up your account and uploading internal applications can be found here: https://ors.duke.edu/sites/default/files/Applicant Instructions_FINAL.pdf

Internal Deadline

April 18, 2016

External Deadline

June 1, 2016