This FOA invites applications for a multisite study to comprehensively characterize the neuropathological features associated with neurodegeneration and neurocognitive decline in persons with a history of traumatic brain injury (TBI).  Investigations should elucidate the contribution of key individual (sex, age at time of injury, time since injury, etc.) and injury characteristics (injury severity and frequency) to describe associations between neuropathological burden and antemortem clinicopathologic symptoms, and outline the prevalence of TBI-related parkinsonism, TBI-related Alzheimer's, and CTE in the participating brain banks. To further advance research in the area, broad sharing of clinical and neuropathological data will be a critical feature of this FOA including the development of a digital resource for distribution and sharing of assessed neuropathological tissue. 

Deadlines:

• Letter of Intent Due Date(s): 30 days prior to the application due date
• Application Due Date(s): April 15, 2019

​RFA-NS-19-030 Expiration Date April 16, 2019