New Computational Methods for Understanding the Functional Role of DNA Variants that are Associated with Mental Disorders (R01 (Collab) Clinical Trial Not Allowed)

Funding Agency:
National Institutes of Health

The purpose of this Funding Opportunity Announcement (FOA) is to support the development of advanced computational, bioinformatic and statistical tools to determine the functional relevance of genetic variants associated with mental disorders of complex etiologies identified through genome-wide association or sequencing studies. The overarching goal of this initiative is to support the development of innovative computational methods that facilitate the elucidation of the functionality of genetic variants associated with mental illness, taking into account the added complexities and nuances of brain diseases, and to ultimately inform novel treatment development based on human biology.

This FOA should be used when two or more sites are needed to complete the study. For a linked set of collaborative R01s, each site must have its own Program Director/Principal Investigator and the set of linked applications provide a mechanism for cross-site coordination, quality control, database management, statistical analysis, and reporting.

Companion FOA: PAR-18-908, R01 Research Project Grant,


  • Letter of Intent Due Date(s): 30 days prior to the application due date
  • R01 Due Dates: Feb. 5, Jun. 5, Oct. 5
  • AIDS Due Dates: Jan. 7, May 7, Sep. 7

PA-18-907 Expiration Date New Date May 8, 2022 per issuance of NOT-MH-21-320. (Original Expiration Date: January 8, 2022)




Engineering and Physical Sciences
Environmental & Life Sciences
Medical - Basic Science
Medical - Clinical Science
Medical - Translational

External Deadline

February 5, 2022