This Notice of Funding Opportunity (NOFO) invites applications for implementation of investigator-initiated multi-site interventional clinical trials (all phases). The trials should be hypothesis-driven, milestone-defined, and related to NIA's research mission. Information about NIA's mission can be found on the NIA website.
R01 Due Dates: Feb. 5, Jun. 5, Oct. 5
PAR-25-222 Expiration Date January 08, 2026
NIA is strongly committed to identifying effective treatments and preventative interventions for diseases and conditions associated with aging by supporting high-quality, meritorious, mission-relevant clinical trials. Trials in older adults face complex ethical, safety, and methodological issues. Among adults 65 to 84 years of age and those older than 85 years, about 65% and 80%, respectively, have been diagnosed with several chronic conditions, and more than a third of this population is taking five or more prescription drugs. Both multimorbidity and polypharmacy significantly increase risk for unexpected disease-disease and drug-disease interactions. In addition, older adults often have difficulties understanding study details, and special measures should be taken to ensure that they give truly independent and informed consent to participate in research studies. This FOA provides a vehicle for submitting investigator-initiated grant applications to conduct multi-site clinical trials of all phases and stages on topics relevant to NIA's mission.