Topics of interest include, but are not limited to:
1) A systematic understanding of how different temporal aspects of stimulation paradigms such as frequency, duration, amplitude, polarity, directionality, and pulse shape interact with endogenous neural activity and neural oscillatory patterns to exert acute and/or lasting effects on CNS function, locally and in distributed networks. Potential approaches could include considerations of spike-field coherence patterns, phase-amplitude coupling, or other aspects of neural functioning.
2) A systematic understanding of how different spatial aspects of stimulation paradigms such as coil design, electrode configuration, and transducer design interact with local anatomy to influence spatial targeting and neuromodulatory effects on CNS function.
3) A systematic understanding of how contextual aspects of neuromodulation paradigms such as the physiological state of the targeted brain area or distributed network prior to and during stimulation, concomitant CNS acting medications, and/or simultaneously applied cognitive/behavioral tasks or interventions influence the acute and/or lasting effects of neuromodulation on CNS function.
4) A systematic test of the interactions between the temporal, spatial, and contextual aspects of stimulation paradigms. A specific example would be an examination of resonance frequencies of different cortical and subcortical areas during rest as well as during effortful, goal-directed tasks in response to neuromodulation.
5) An understanding of how task-specific circuits are modulated differently by the same stimulation parameters. For example identical stimulation parameters applied to the same brain area might have very different effects on ongoing endogenous activity depending on whether the subject is engaged in a task utilizing non-spatial working memory versus a spatial navigation task.
6) An understanding of what parameters lead to shorter and/or longer-duration changes in network activity.
7) An understanding of how the effectiveness of modulation parameters varies with brain maturation (children, adolescents, older adults vs. young adults), sex, and cognitive-affective state. These variables may also play a role in effectiveness of exogenous stimulation/modulation.
Application budgets need to reflect the actual needs of the proposed project. The budgets are limited to $375,000 direct costs annually.
The scope of the proposed project should determine the project period. The maximum project period is 5 years.