Sponsor Deadline
Posted: 4/18/2022

NIH Countermeasures Against Chemical Threats (CounterACT) Research Centers of Excellence (U54 - Clinical Trial Optional)

This Funding Opportunity Announcement (FOA) encourages applications for Countermeasures Against Chemical Threats (CounterACT) Research Centers of Excellence (U54s). The mission of the NIH CounterACT program is to foster and support research and development of new and improved therapeutics for chemical threats. Chemical threats are toxic chemicals that could be used in a terrorist attack or accidentally released from industrial production, storage or shipping. They include traditional chemical warfare agents, toxic industrial chemicals, pharmaceutical-based agents, and pesticides.  The scope of the research includes target and lead candidate identification and characterization, through lead candidate optimization and demonstration of in vivo efficacy consistent with the product's intended use in humans as a medical countermeasure. For applicants submitting U54 renewal applications, research under this FOA should culminate in an optimized lead compound ready for advanced development. The Centers will contain at least three research projects supported by an administrative core, up to three optional scientific cores, a research education core, and a pilot project program to support short-term innovative research and recruitment of new investigators into the field of medical countermeasures research. Each research project must include milestones that create discrete go or no-go decision points in a progressive translational study plan.   Companion FOAs:

PAR-20-253, R21 – Exploratory/Developmental

PAR-19-039, U01 – Cooperative Agreements

PAR-19-040, U01 – Cooperative Agreements



  • Letters of Intent Receipt Date(s): 30 days before the application due date
  • Applications: September 14, 2021, September 13, 2022, September 12, 2023.  

PAR-20-316 Expiration Date: New Date October 1, 2021 per issuance of NOT-NS-22-029.

Amount Description

Application budgets may not exceed $1.75 million in direct costs per year.

Many applications will not need to request the maximum budget and the size and duration of the awards will vary because the nature and scope of research programs will vary.

The total project period may not exceed five years.

Funding Type