NIH Director's Pioneer Award (DP1 - Clinical Trial Optional)

Funding Agency:
National Institutes of Health

The NIH Director’s Pioneer Award Program supports individual scientists of exceptional creativity who propose highly innovative research projects with the potential to produce a major impact on broad, important areas relevant to the mission of NIH. For the program to support the best possible researchers and research, applications are sought which reflect the full diversity of the nation’s research workforce. Thus, individuals from all backgrounds and from the full spectrum of eligible institutions in all geographic locations are strongly encouraged to apply to this Funding Opportunity Announcement. In addition, applications in all topics relevant to the broad mission of NIH are welcome, including, but not limited to, topics in the behavioral, social, biomedical, applied, and formal sciences and topics that may involve basic, translational, or clinical research. To be considered pioneering, the proposed research must reflect substantially different scientific directions from those already being pursued in the investigator’s research program or elsewhere. The NIH Director’s Pioneer Award is a component of the High-Risk, High-Reward Research (HRHR) Program of the NIH Common Fund.


  • Application Due Date(s): September 8, 2023
  • AIDS Application Due Date: September 8, 2023

RFA-RM-23-004 Expiration Date: September 09, 2023

Agency Website

Eligibility Requirements

Applicant organizations may submit more than one application, provided that each application is scientifically distinct. Individuals may submit only one application as a PD/PI in response to this FOA.

Only single PD/PI applications are allowed. Applications with multiple PD(s)/PI(s) will not be accepted.



Amount Description

Awards will be for $700,000 in direct costs per year, plus applicable Facilities and Administrative (F&A) costs.

The project period is limited to five years.

Funding Type





Engineering and Physical Sciences
Environmental & Life Sciences
Medical - Basic Science
Medical - Clinical Science
Medical - Translational
Social Sciences

External Deadline

September 8, 2023