NIH-DoD-VA Pain Management Collaboratory - Coordinating Center (U24)

Funding Agency:
National Institutes of Health

The purpose of this FOA is to solicit applications for a Coordinating Center (CC) to provide national leadership for the NIH-DoD-VA Health Care Systems (HCS) Research Collaboratory program on non-pharmacological approaches to pain management and comorbidities in U.S. military personnel, veterans and their families. For brevity, this initiative will be referred to as the “NIH-DoD-VA Pain Management Collaboratory.” Coordinating Center applicants will need to: 1) develop, adapt, and adopt technical and policy guidelines and best practices for the effective conduct of research in partnership with health care systems focused on military personnel, veterans, and their families;  2) work collaboratively with and provide technical, design, and  other support to Demonstration Project teams, to develop and implement a pragmatic trial protocol; and 3) disseminate widely Collaboratory-endorsed policies and best practices and lessons learned in the Demonstration Projects for implementing research within health care settings. The Coordinating Center will also serve as the central resource for the activities of the NIH-DoD-VA Pain Management Collaboratory program, including providing administrative support for a Steering Committee and its subcommittees. 

Demonstration Projects, solicited under a separate companion FOA (RFA-AT-17-001), will be selected based on the importance of the scientific questions and the potential to address impediments to research on non-pharmacological approaches to pain management and other comorbid conditions in health care delivery organizations serving military personnel, veterans and their families. 


  • Letter of Intent Due Date(s): 30 days prior to the application due date
  • Application Due Date(s): March 3, 2017

RFA-AT-17-002 Expiration Date March 4, 2017

Agency Website

Eligibility Requirements

In terms of experience and expertise, in addition to a strong experienced leader, the Coordinating Center PD/PI should have the following qualities:

  • Technical expertise in accessing and extracting information from electronic health records (EHRs) of the health care systems that deliver care to all of the following groups: U.S. military, veterans, and their families and relevant clinical systems for research purposes;
  • Knowledge of the regulatory requirements for conducting pragmatic clinical trials within both military and veteran health systems including knowledge of policies and procedures for the use of health care data for research purposes and experience in conducting research that complies with clinical practice and research regulations for these systems.
  • Experience with the ethical issues related to pragmatic clinical trials, clinical care, quality improvement, population health, and surveillance. Specifically, knowledge of the human subjects protection requirements for military and veteran health care systems.
  • Ability to provide technical support for multisite pragmatic clinical trials involving multiple health care delivery organizations providing services to military personnel, veterans and their families.
  • Experience working with a variety of stakeholders including patients, research participants, practitioners, researchers, hospital and research informatics and technical personnel, and senior managers of health care and research organizations on workflows and practices of military and veteran health care systems.
  • Knowledge of workflows and research team practices in design and implementation of pragmatic clinical trials.
  • Knowledge of current data models, algorithms, and approaches used by the various eligible networks and practices to define clinical phenotypes, extract information, define endpoints, and discover errors in data.
  • Knowledge of privacy regulations related to both the military and veteran health care systems
  • Project management experience in taking a research question from idea, through implementation, to completion.
  • Study design and statistical expertise, particularly in pragmatic clinical trial methodology, including cluster randomization and stepped-wedge designs.
  • Ability to solve technical challenges effectively and respectfully with all relevant communities.
  • Knowledge of patient reported outcomes and patient reported assessments in health care EHRs of military and veteran health care systems, research study management tools, including electronic transfer of information from mobile and other devices.

Amount Description

Direct costs requested for the first three years may not exceed $1.3 million per year;  direct costs for years 4 to 6 may not exceed $1.0 million per year. 

The total project period for an application submitted in response to this FOA may not exceed 6 years.   

Funding Type





Medical - Basic Science
Medical - Clinical Science
Social Sciences

External Deadline

March 3, 2017