NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Required)

Funding Agency:
National Institutes of Health

The NIH Exploratory/Developmental Grant supports exploratory and developmental research projects by providing support for the early and conceptual stages of these projects. These studies may involve considerable risk but may lead to a breakthrough in a particular area, or to the development of novel techniques, agents, methodologies, models, or applications that could have a major impact on a field of biomedical, behavioral, or clinical research. This Parent Funding Opportunity Announcement requires that at least 1 clinical trial be proposed. The proposed project must be related to the programmatic interests of one or more of the participating NIH Institutes and Centers (ICs) based on their scientific missions.

Applicants should note that some ICs (seeRelated Notices) only accept applications proposing mechanistic studies that meet NIH's definition of a clinical trial through this funding opportunity announcement.

Companion FOAs:

PA-20-195, Parent R21 Exploratory/Developmental Grant, Clinical Trial Not Allowed

PA-20-196, Parent R21 Exploratory/Developmental Grant, Basic Experimental Studies with Humans Required


  • R21 Deadlines: Feb. 16, Jun. 16, Oct. 16.
  • AIDS Deadlines: Jan. 7, May 7, Sep. 7.

PA-20-194 Expiration Date: New Date May 8, 2024 per issuance of NOT-OD-23-105. (Original Expiration Date: May 8, 2023)

Agency Website



Amount Description

The combined budget for direct costs for the two-year project period may not exceed $275,000. No more than $200,000 may be requested in any single year.

 The total project period may not exceed 2 years.

    Funding Type



    Junior Faculty


    Engineering and Physical Sciences
    Environmental & Life Sciences
    Medical - Basic Science
    Medical - Clinical Science
    Medical - Translational
    Social Sciences

    External Deadline

    February 16, 2024