The purpose of this funding opportunity announcement (FOA), issued by the NINDS, is to invite currently awarded NIH StrokeNet centers and potential new stroke centers to participate as a Regional Coordinating Stroke Center (RCC) in the NIH StrokeNet clinical trials network. Established by the NINDS in 2013, the goal of the NIH StrokeNet is to harness the leadership and experience of the stroke research field to maximize efficiencies for developing, promoting, and conducting high-quality, multi-site clinical trials focused on promising interventions for stroke prevention, treatment, and recovery with the objective of having a balanced portfolio between all three approaches. Multi-site exploratory and confirmatory Phase 3 clinical trials as well as biomarker-validation studies that are immediately preparatory to trials and ancillary studies designed to add scientific aims to active studies will be coordinated through separate National Coordinating (NCC) and National Data Management (NDMC) Centers.
Funded RCCs in the network will be regional academic medical centers that include geographically or organizationally linked partners, clinical performance sites, or satellite stroke centers that are committed to randomizing patients in NINDS-funded NIH StrokeNet clinical studies. RCCs will have both clinical science excellence and specialized expertise in stroke management, as well as a strong background in stroke research, and a proven ability to recruit stroke patients. Each RCC will also have strong collaborative relationships between vascular neurology, emergency medicine, interventional neuroradiology, neurosurgery, neurointensive care, neuroimaging, stroke rehabilitation, and pediatric neurology, thereby demonstrating commitment to offer all eligible patients the opportunity to participate in a trial conducted through the network. In addition, the NIH StrokeNet clinical trials network will include an active stroke research career advancement program. RCCs will be committed to advancing the career of junior stroke research fellows and research coordinators to ensure a strong continuity of academic stroke research in the future. Lastly, all RCCs will be committed to increasing the value of clinical research data through an aggressive data sharing plan.
This FOA solicits applications for the RCCs for the NIH StrokeNet. Separate FOA's solicit applications for the NCC and NDMC.
Only one RCC application per institution (normally identified by having a Unique Entity Identifier or NIH IPF number) is allowed. Interested applicants from within Duke should contact fundopps@duke.edu as early as possible.
Application Deadline: Feb. 28, 2023
RFA-NS-23-010 Expiration Date March 01, 2023
Only one RCC application per institution (normally identified by having a Unique Entity Identifier or NIH IPF number) is allowed.
Awards for a RCC and a NCC may be made to the same institution. However, it is preferable that the NCC and the RCC grant at a given institution support two different investigators, to ensure that the NCC activities as well as the local RCC activities receive full attention.
Awards for a RCC and a NDMC may be made to the same institution. However, investigators on the RCC award are not permitted to have any role in the NDMC award to ensure that the NDMC activities as well as the local RCC activities are independently managed.
A RCC may be from a single institution or may include geographically or organizationally linked partners or satellite sites, such as other academic centers and/or private and community hospitals and clinics as needed to fulfill the research requirements; however, it is preferable that only one principal investigator be identified for the RCC application.
The maximum allowable direct cost per year for a NIH StrokeNet RCC will be $275,000.
The project period is limited to 5 years.
