Non-invasive Diagnostics to Improve Gynecologic Health (R43/R44 Clinical Trial Optional)

Funding Agency:
National Institutes of Health

The purpose of this funding opportunity announcement (FOA) is to encourage small businesses to collaborate with scientists and clinicians in the field of gynecologic health to develop, advance, and validate new devices and methods for non-invasive diagnosis and/or screening of endometriosis, adenomyosis, and/or uterine fibroids. Projects supported will aim to shorten the time to diagnosis, decrease the invasiveness of current techniques, and/or improve accessibility, safety, convenience, and costs of diagnosis and/or screening.


  • Letter of Intent Due Date(s): November 10, 2020
  • Application Due Date(s): December 10, 2020

RFA-HD-21-020 Expiration Date December 11, 2020

Agency Website

Areas of Interest

his initiative requires that the research projects address areas of research that are directly relevant to any one of the following conditions:

  • Fibroids
  • Endometriosis
  • Adenomyosis

The scope of this FOA includes applied translational and clinical projects that will enable the development of more effective strategies for the diagnosis and/or screening of the selected gynecologic condition. Project aims that utilize mammalian model systems are acceptable, provided that such studies have a clear path for eventual translation to humans. Of note, approaches that can be used to screen for the absence of these conditions (normal gynecologic function with regard to endometriosis, adenomyosis, and fibroids) are also of interest. Emphasis on early detection is especially encouraged. Additionally, collaboration with investigators and/or small businesses that have not previously applied their expertise to gynecological health research is encouraged.

For the purpose of this FOA, non-invasive procedures will be defined as procedures that do not require incision or contact with a bodily orifice beyond natural orifices. Venipuncture, finger pricks, and transvaginal imaging modalities will be considered responsive to this FOA.

    Eligibility Requirements

    Only United States small business concerns (SBCs) are eligible to submit applications for this opportunity.

    Funding Type





    Engineering and Physical Sciences
    Medical - Clinical Science
    Medical - Translational

    External Deadline

    December 10, 2020