Notice of Intent to Publish Funding Opportunity Announcements for Research to Develop, Demonstrate, and Validate Experimental Human Tissue Models that Do Not Rely on Human Fetal Tissue

Funding Agency:
National Institutes of Health

The National Institutes of Health intends to publish new Funding Opportunity Announcements (FOAs) to invite applications to develop and/or further refine human tissue models that closely mimic and can be used to faithfully model human embryonic development or other aspects of human biology, for example, the human immune system, that do not rely on the use of human fetal tissue obtained from elective abortions. Research proposals may include using these models to understand human tissue development, function, and disease. Types of studies that should be submitted under these FOAs include research to develop alternative models to the use of human fetal tissue in biomedical research. These may include cell culture models using induced pluripotent stem cells (iPSC), iPSC-derived organoids, or other three-dimensional culture systems. Studies may also include new approaches or advances on existing methods to significantly improve current approaches to recapitulate the human immune system. NIH plans to publish FOAs in the coming months for funding to begin in FY19 and FY20. FOAs will be published using a variety of activity codes, including but not limited to: R01, R21, U01, and R43. Supplements also will be used to augment ongoing activities.

Agency Website

Amount Description


Funding Type





Environmental & Life Sciences
Medical - Basic Science
Medical - Clinical Science
Medical - Translational