Notice of Special Interest: Administrative Supplements to Advance Precision Medicine Using the All of Us Research Program’s Data

Funding Agency:
National Institutes of Health

The All of Us Research Program (All of Us) within the Office of the Director (OD) encourages eligible grantees of the participating Institutes, Centers, and Offices (ICOs) to apply for administrative supplements to support analysis of currently available data within the All of Us Research Program’s Researcher Workbench or to develop analysis tools for the available data within the general scope of the parent award.

Background

The All of Us Research Program is building a database to help transform the future of health research by equipping researchers nationwide with expansive health data from diverse populations, especially those underrepresented in biomedical research. It is built in partnership with participants spanning different ages, races and ethnicities, and regions of the country. New data are added twice a year. Available to registered researchers includes:

  • data from 329,000+ participants [about 50% racial and ethnic minorities, 80% from communities underrepresented in biomedical research overall (including racial and ethnic minorities, sexual and gender minorities, people living in rural areas, and other groups)].
  • whole genome sequence data from nearly 100,000 participants (nearly 50% of whom self-identify as a member of a racial or ethnic minority group)
    • 593,000,000+ unique variants, which Include 100M+ variants with = 3 occurrences not seen in gnomAD 3.0 (n = 71,702)
  • electronic health record data from 214,200+ participants (including demographics, visits, diagnoses, COVID diagnoses and medications)
  • survey data from 329,000+ participants from seven different questionnaires capturing participant data on lifestyle, health care utilization and access, and COVID-19 participant experience.
  • Fitbit data from more than 11,600+ participants who linked their personal data to their All of Us account
  • physical measurements from 267,000 participants (including blood pressure, heart rate, BMI, and more)

The All of Us dataset, available to scientists across the United States, provides unprecedented opportunities for a wide range of studies to understand how biological, behavioral, and environmental factors influence health and a broad range of diseases and conditions. The All of Us data are housed on the Researcher Workbench, which also includes tools, along with personalized support resources, such as an integrated help desk, regular office hours, sample datasets and more.

This announcement is for supplements to existing projects. To be eligible, the parent award must be active when the supplemental application is submitted (i.e., within the originally reviewed and approved project period). The parent award must be able to receive funds in FY22. The research proposed in the supplement must be accomplished within the competitive segment. Awards in a No-Cost Extension (NCE) or going into a no-cost extension in FY22 are not eligible.

NIH institutional training grants (Ts), research career development awards (Ks), fellowships (Fs), and other non-traditional research awards [Research Education Program (R25)] are not eligible to apply.

Application Due Date(s) – July 5, 2022

NOT-PM-22-002

Eligibility

Faculty

Category

Environmental & Life Sciences
Medical
Medical - Basic Science
Medical - Clinical Science
Medical - Translational
Social Sciences

External Deadline

July 5, 2022