Notice of Special Interest (NOSI): Administrative Supplement for Continuity of Biomedical and Behavioral Research Among First-Time Recipients of NIH Research Project Grant Awards

Funding Agency:
National Institutes of Health

This is the reissuance of Notice of Special Interest (NOSI): Administrative Supplement for Continuity of Biomedical and Behavioral Research Among First-Time Recipients of NIH Research Project Grant Awards (NOT-OD-20-055). The overarching goal of this program is to enhance the retention of investigators facing critical life events who are transitioning to the first renewal of their first independent research project grant award or to a second new NIH research project grant award. Retention at the first renewal or continuous NIH research project grant support is crucial for sustaining both the ongoing research NIH has made an investment in and for retaining diverse talent in the biomedical research workforce. This program supports “at-risk” investigators as identified in the NIH Next Generation Researchers Initiative (see

This retention program seeks to maintain the productivity of current first-time recipients of eligible independent NIH research project grant awards who are dealing with a critical life event(s), such that they can remain competitive for the first renewal of their award or for a second research project grant award. For retention supplements to support the transition from K award to independence, see the companion NOSI (NOT-OD-23-031).

Investigators, especially women, leave science at critical transition stages or branching points in their career which for the NIH-supported scientific workforce include transitions from post-doctoral training to faculty positions (Heggeness et al., 2016 Aug; 91(8):1164-72, Acad MedNikaj et al., 2019, the FASEB Journal) and prior to obtaining their first R01 renewal (Hechtman et al., 2018: 115(31)7943-7948, PNAS). The rate of R01/R01-equivalent renewals has potential impact on the longevity of an investigator’s research career (Pohlhaus et al., 2011 Jun; 86(6):759-67, Acad Med) and there remains a gender disparity in NIH funding that should be addressed. These vulnerable career stages often parallel critical life events that commonly contribute to faculty attrition. Data from NSF demonstrate that among biomedical scientists and engineers, women are far more likely than men to cite family responsibilities as a reason for being unemployed or leaving the workforce. (NCSES Report – Employment, especially figure 30).

Pregnancy and childbirth in particular, appear to be significant contributors to the underemployment of women scientists and engineers given that pregnancy can impact research productivity (Cech and Blair-Loy, 2019 116(10)4182-4187, PNAS The Changing career trajectories of new parents in STEM; Powell, 2021, Nature The parenting penalties faced by scientist mothers). The demands of childbirth and subsequent primary caregiving responsibilities may necessitate changes to career goals and alter researchers career trajectories, depriving the scientific workforce of an important source of talent and undermining NIH’s investment in promising avenues of new research. Retaining investigators at this critical transition point will protect the research investment already made via the parent NIH award and enhance the diversity of the investigator pool.


Expiration Date: October 01, 2025

Agency Website

Eligibility Requirements

To be eligible, the parent award must typically be able to receive funds at the time of the award. The administrative supplement budget request is limited to 1 year.

Supplement budget requests cannot exceed $70,000/year direct costs, and applicable F&A (indirect) cost can also be requested. Budgets may not exceed the total direct costs of the current parent award. Requests must reflect the actual needs of the proposed project. Categorical budgets are permitted. Awards are subject to availability of funds.

Flexible use of supplemental funds is highly encouraged, including but is not limited to computational services, supplies, equipment, and supported effort of additional scientific staff to sustain the PD/PI’s research during a critical life event. Supplement funds may not be used for PI salary support during the regular or extended period of the grant.

PD/PIs of the following activity codes are eligible for the program: DP1DP2DP5R01R00R15, R16R21R34R35RF1R37 and U01.PD/PIs with more than one independent research project grant award are ineligible for this supplement.

Qualifying Critical Life Events: The PD/PI must demonstrate a critical life event during the parent grant project period, such as childbirth, adoption, serious personal health issues or illness and/or debilitating conditions, high-risk pregnancy, primary caregiving responsibilities of an ailing spouse, child, partner, parent, or a member of the immediate family. In circumstances in which the critical life event is pending and is expected to occur during the project period, the supplement period may be submitted in advance of the event. Detailed personal health information such as specific diagnoses or medical conditions is not required or necessary to be considered for this supplement.

For supplements to parent awards that include multiple PDs/PIs, the supplement may be requested by any of the PDs/PIs (in accordance with the existing leadership plan and on behalf of the PD/PI who meets the eligibility criteria) and submitted by the grantee institution of the parent award. It should be noted that for the parent grant and for the administrative supplement, the grantee is the institution, not the PD/PI.

Funding Type



Junior Faculty
Post Doctoral Fellows


Medical - Basic Science
Medical - Clinical Science
Medical - Translational

External Deadline

September 30, 2025