Aiming to improve human health, the NIH Bench-to-Bedside and Back Program (BtB) Program (https://ocr.od.nih.gov/btb/btb_program.html) supports innovative small/pilot research projects designed to translate basic scientific findings into therapeutic interventions for patients and to increase understanding of important clinical observations of disease processes. It promotes robust multi-directional collaborations among laboratory ("bench") and patient-focused ("bedside") investigators. Through the NIH BtB Program, this funding opportunity will invite two-year administrative supplement applications for collaborations between the NIH intramural research investigators, who conduct translational and clinical research and extramural NIH recipients. Every project must include an NIH intramural investigator who is responsible for submitting the BtB Letter of Intent (LOI) and application online (Proposal Central; PC; https://proposalcentral.com/).

This NOSI is intended for the extramural collaborators of awarded Bench to Bedside (BtB) proposals. Selected Applicants will be notified by the BtB Program Officer to apply for an administrative supplement in response to this NOSI. Projects may have single or multiple Principal Investigator(s). Extramural investigators may initiate or lead projects, though the extramural investigator must still have an intramural collaborator. Extramural investigators who need assistance identifying Intramural partners may consult:

• NIH’s database of all current intramural research at http://intramural.nih.gov/search/index.tml;
• Intramural Principal Investigator Directory at http://irp.nih.gov/our-research/principal-investigators;
• “Search the Studies” website to identify investigators on relevant protocols at https://clinicalstudies.info.nih.gov/; or
• BtB Program Office (BenchtoBedside@mail.nih.gov) for assistance in identifying Intramural partners.

Applications must be received by 5 pm local time of the submitting institution on the following: March 6, 2023.

NOT-OD-22-185