Notice of Special Interest (NOSI): Availability of Administrative Supplements for Research on Pain, Pain Management, and Opioids in Aging

Funding Agency:
National Institutes of Health

The National Institute on Aging (NIA) is interested in receiving administrative supplement applications to parent awards that are already focused on pain, pain management, or opioids related to aging or older adults. This NOSI invites administrative supplements within the scope of the parent award that focus on improving the understanding of mechanisms underlying pain experience with aging; enhancing assessment, prevention, and management strategies for pain in older adults; and improving health equity of aging populations suffering with pain. For new applications, resubmissions, competing renewals, and competing revisions to existing awards focused on pain, pain management, and opioids related to aging or older adults and within NIA’s mission areas, please see NOT-AG-22-004.

The specific research objective of this NOSI is to expand the scientific knowledge base of mechanisms, assessment, treatment, and outcomes of pain and pain-related conditions in aging humans and animal models. NIA welcomes basic and translational research supplements that fall within NIA’s mission to support genetic, biological, clinical, behavioral, social, and economic research on aging. Both new data collection and analyses of existing datasets are welcome. Leveraging of ongoing cohorts, intervention studies, networks, data and specimen repositories, model systems, and other existing research resources and infrastructure is encouraged. Study designs may include mechanistic studies, observational approaches, quasi-experimental designs, and interventional studies. NIA encourages applicants to address priorities outlined in the NIA Health Disparities Research Framework (

Administrative supplement applications should focus on aging-related studies of pain, pain management, or opioids. Topic areas of interest include, but are not limited to:

  • Elucidation of mechanisms underlying pain experience and its consequences in aging
  • Development and enhancement of strategies for collection of clinical pain data and for assessing, preventing, and managing pain in later life
  • Improving health equity of aging populations suffering from pain

Application Due Date(s) – April 28, 2022





Medical - Basic Science
Medical - Clinical Science
Medical - Translational

External Deadline

April 28, 2022