The purpose of this Notice of Special Interest (NOSI) is to encourage P01 Research Program Project applications designed to address adverse sequelae of cancer therapies (including chemotherapy and radiation) that persist and become chronic comorbidities or develop as delayed posttreatment effects. The research focus of proposals should build upon mechanistic studies and include clinical phenotyping of adverse sequelae, the development and implementation of prevention or mitigation strategies, and validation of pre-clinical biomarkers in the clinical setting. Proposals should be focused on clinical and translational research supported by preliminary mechanistic research.
NCI is interested in grant applications that extend the mechanistic understanding of cancer therapy induced adverse sequelae to address one or more of the research gap areas outlined below. Program Projects should address hypotheses supported by mechanistic data through projects focused on clinical and translational outcomes. Applications may focus on adverse sequelae that persist and become chronic co-morbidities or develop as delayed posttreatment effects related to radiation and/or systemic therapy (chemotherapy, immunotherapy, targeted or hormonal therapies).
This notice applies to due dates on or after January 25, 2021, and subsequent receipt dates through May 8, 2023.