Notice of Special Interest (NOSI): Fundamental Science Research on Complementary and Integrative Health Approaches

Funding Agency:
National Institutes of Health

The purpose of this Notice of Special Interest (NOSI) is to describe NCCIH priorities in innovative basic and mechanistic research or technology/method development research relevant to complementary and integrative health approaches.

Complementary health approaches include a broad range of practices and interventions that are not typically part of conventional medical care. Complementary approaches can be classified by their primary therapeutic input, which may be dietary (e.g., special diets, dietary supplements, herbs, probiotics, and microbial-based therapies), psychological (e.g., meditation, hypnosis, music-based interventions, relaxation therapies), physical (e.g., acupuncture, massage, chiropractic manipulation, devices related to these approaches), or a combination of psychological and physical (e.g., yoga, tai chi, dance therapies, some forms of art therapies). The dietary approaches include what have been previously categorized as natural products, whereas psychological and/or physical approaches encompass what have been commonly referred to as mind and body interventions. Integrative health brings conventional and complementary approaches together in a coordinated way. Integrative health also emphasizes multimodal interventions that aim to improve health in multiple interconnected domains—social, psychological, and physical, including multiple organs and systems.

Basic and mechanistic research on complementary and integrative health approaches should investigate the following key aspects. The first is the approach (also called intervention) itself, the second is the biological, behavioral, psychological, and/or social systems potentially targeted by the approach or intervention, and the third is the platform in which they will be studied (e.g., cell cultures, animal models, human subjects, or a computational model/in silico system). In the context of complementary and integrative health approaches, mechanistic research often refers to studies examining the interactions between the approach and the systems (e.g., biological, behavioral, psychological, and/or social), whereas basic research may investigate either the approach or intervention itself, the systems without the interactions, or the associated technologies. When basic research is pursued, applicants are encouraged to articulate the relevance of their basic or technological/method development research to a complementary or integrative health approach if the approach is not to be directly studied.

This notice follows standard receipt dates and applies to due dates on or after June 5, 2021 and subsequent receipt dates through September 7, 2024.






Engineering and Physical Sciences
Environmental & Life Sciences
Medical - Basic Science
Medical - Clinical Science
Medical - Translational

External Deadline

February 5, 2024