The purpose of this Notice of Special Interest (NOSI) is to stimulate research and advancement of methodologies in data science in heart, lung, blood, or sleep (HLBS) biomedical research, and ultimately translate new insights into decision-making to improve health.
The objectives of this Notice are to: (1) stimulate the advancement of novel data science methodologies for gaining new insights; (2) enable innovative engineering solutions for better and faster data analytics; and (3) communicate research outputs through open-science platforms. The scope of the scientific issues and challenges must be of relevance to the NHLBI’s mission and aligned with the NHLBI Strategic Vision.
The innovative methodologies of data science may focus on either single or multiple algorithms in AI and ML. Study designs may be in basic, pre-clinical, clinical, clinical implementation, and public health, or a combination of these phases. The sources of data may come from any study design phase or from real-world data/real-world evidence, such as electronic medical/health record systems (EMR/EHR), product and disease registries, mobile devices, Internet of Things (IOTs), social media, geospatial environments, etc. A complementary, multi-disciplinary, Multi-Principal Investigators (MPIs) approach is encouraged to address the Critical Challenges/Compelling Questions of the NHLBI’s Strategic Vision, NIH Publication 16-HL-6150.
Sharing of resources and effective communication of outputs to the broader scientific community is an essential element of applications. Research plans that actively adhere to open-science and FAIR (Findable, Accessible, Interoperable, and Reusable) principles would be of greatest interest to NHLBI. Research outputs may include but not be limited to open-source, reusable, high-quality metadata; smart tools; algorithms; documentation; supplemental materials; presentations at conferences or publications containing guidelines with examples, tutorials, and source code.
For the integrative omics analysis of NHLBI TOPMed data, please check NOT-HL-21-017.
NOTE: For this NOSI, NHLBI will only accept applications in response to PA-20-183 and PA-20-185. For PA-20-183, only mechanistic clinical trials will be accepted in accordance with NOT-HL-19-690. Applicants wishing to propose non-mechanistic clinical trials may consider applying to one of the NHLBI clinical trial mechanisms described at https://www.nhlbi.nih.gov/grants-and-training/clinical-trial-development-continuum. Non-mechanistic clinical trials submitted in response to this NOSI via PA-20-183 will be withdrawn.
NOT-HL-22-001
Expiration Date: January 08, 2025