Notice of Special Interest (NOSI): Methods Development in Natural Products Research (SBIR/STTR)

Funding Agency:
National Institutes of Health

The purpose of this Notice of Special Interest (NOSI) is to support small businesses for stimulation of technological innovation in natural products research. For the purposes of this NOSI, natural products include prebiotic, probiotic, herbal, botanical, microbial, and animal sources as well as extracts or constituents derived from them. Natural products offer a diverse reservoir of biologically active components. The single chemical entities, as well as their mixtures in natural product extracts, have a long history of use as drugs, drug precursors, and/or complementary health adjuvants. However, methodologies for the identification of bioactive natural products and their mechanism(s) of pharmacological action are often inadequate or too time consuming to be compatible with modern screening platforms. Potentially, many existing biotechnologies could be adapted to improve natural products research. Innovative methods may utilize genomics, bioengineering, bioinformatics, synthetic and molecular biology, and/or nanotechnology. These new and innovative methodologies and technologies should increase the efficiency of research in this field.

With this NOSI via the omnibus solicitation, NCCIH is proposing to focus on areas that could significantly improve progress in natural products research. This NOSI is intended to help move useful technologies into the commercial marketplace by inviting grant applications from small businesses for further development of such technologies that are relevant to the missions of the sponsoring NIH institutes and centers. The supported research and development will likely include making the tools more robust and easier to use.

This Notice applies to due dates on or after September 05, 2020 and subsequent receipt dates through September 05, 2023.


Agency Website

Eligibility Requirements

Only United States small business concerns (SBCs) are eligible to submit applications for this opportunity.

Funding Type





Engineering and Physical Sciences
Environmental & Life Sciences
Medical - Basic Science
Medical - Clinical Science
Medical - Translational

External Deadline

September 5, 2023