Notice of Special Interest (NOSI): Neuromodulatory Control of Circuits Underlying Mental Health Relevant Behaviors

Funding Agency:
National Institutes of Health

This Notice of Special Interest (NOSI) solicits applications seeking to understand how neuromodulatory signals dynamically control and coordinate neural circuit responses in real-time during complex mental health relevant behaviors including cognitive, social, and affective functions. These studies are expected to utilize recent tools that enable precise assessment of spatiotemporal dynamics of extracellular release or receptor activation of neuromodulators with simultaneous causal interrogation of neural activity and behavioral responses.

This notice applies to due dates on or after February 5, 2024 and subsequent receipt dates through May 10, 2027. 


Agency Website

Areas of Interest

Examples of specific research areas of interest include, but are not limited to, the following:

  • Temporal dynamics of neuromodulators and neuropeptides and subsequent effects on neural circuit activity and behavior across a range of timescales
  • Characterizing the impact and spatiotemporal dynamics of multiple neuromodulators release at the circuit level and their functional role of action on behavior (Applications focusing on co-transmission should target research topics represented in NOT-MH-24-105)
  • Coordination of neuromodulator signaling across spatially distributed circuits spanning multiple circuits and/or microcircuits
  • Neuromodulatory effects on circuits during early/sensitive periods of development in combination with causal approaches for circuit manipulation to assess relations between aberrant circuit function and maladaptive behavioral trajectories
  • Computational models integrating detailed spatiotemporal neuromodulatory signaling with ionotropic neurotransmission and neuronal dynamics (e.g., to make predictions about mechanisms of neuromodulatory impact on network dynamics and behavior)
  • Role of neuromodulatory effects on neuron-glia spatiotemporal activity and its relation to cognitive and social-affective behaviors. For example, addressing how neuromodulatory levels, glia activation, and neuronal output coordinate across different spatiotemporal timescales
  • Cell-type specificity in both the populations of neuromodulatory cells and their downstream targets within brain-wide circuits underlying mental health-relevant behaviors

Funding Type





Engineering and Physical Sciences
Medical - Basic Science
Medical - Clinical Science
Medical - Translational

External Deadline

June 5, 2024