This Notice of Special Interest informs current awardees that the National Center for Advancing Translational Sciences (NCATS) is providing another opportunity for supplemental funding to support deposition of data generated from tissue chips (also known as microphysiological systems, or “organs on chips”) into the NCATS-funded Microphysiology Systems Database (MPS-Db).
This Notice announces the availability of administrative supplements for active awards (e.g., award not in an extension period) funded through the he NIH Microphysiological Systems (MPS) Program under the following Funding Opportunities (Note: Administrative supplement projects must be within the scope of the parent award.):
- Tissue Chips for Disease Modeling and Efficacy Testing (RFA-TR-16-017)
- “Clinical Trials” on a Chip (RFA-TR-19-014)
- Tissue Chips in Space (RFA-TR-16-019 and RFA-TR-18-001)
- HEAL Initiative: Tissue Chips to Model Nociception, Addiction and Overdose (RFA-TR-19-003)
- ImmuneChip: Engineering Microphysiological Immune Tissue Platforms (PAR-19-138)
- Human Three-Dimensional Cell Model Systems for Alzheimer’s Disease-Related Dementias (RFA-NS-19-027); or
- SBIR/STTR-supported investigators, provided the award involves tissue chips.
There is a critical need for publicly accessible data generated from tissue chips to inform researchers about the types of data that can be generated from MPS, as well as the reliability and reproducibility of platforms and their resulting data. The MPS-Db, funded and supported by NCATS through the University of Pittsburgh Drug Discovery Institute, is an online resource that houses tissue chip data and provides tools for reviewing, analyzing and modeling data, which can inform stakeholders on assays, models, cell sources, and responses to compounds. The MPS-Db aggregates MPS data with linked preclinical and clinical databases for analysis in the context of human exposure. The MPS-Db also facilitates submission of data on disease models and is expanding a specific disease model portal. Built-in tools enable the assessment of the reproducibility and transferability of MPS models, while computational models embedded in the Db are designed to enhance the value of MPS models for understanding disease mechanisms, compound toxicity, and prediction of drug pharmacokinetics (PK). This information is important for tissue chip technology validation efforts and contributes significantly to informing researchers on appropriate contexts-of-use of specific platforms and contributes towards validation and standardization of MPS platforms.
Data that have already been generated are eligible for submission, as are data that are yet to be generated as described in the project milestones.
All initiatives within the NIH Microphysiological Systems Program are funded with the expectation that all data acquired from funded projects will be managed in a coherent database that will be available to government and private partners. Additionally, upon completion or termination of the project, all data are expected to be publicly available according to the NIH-approved plan submitted for each project.
Expiration Date: June 19, 2021