Notice of Special Interest (NOSI) regarding the Availability of Administrative Supplements for Tissue Chips Research on the 2019 Novel Coronavirus

Funding Agency:
National Institutes of Health

NCATS is issuing this Notice of Special Interest (NOSI) to highlight the urgent need for research on the COVID-19. NCATS is especially interested in research in the use of microphysiological systems or tissue chips in collecting and examining data on the risks and outcomes for COVID-19 infection, and advance the translation of research findings into diagnostics, therapeutics, and vaccines.

A multi-organ on chip approach is strongly encouraged though not required. Please document access to a BSL-3 facility or include scientific justification for use of alternative facilities, for example using an engineered a COVID-19 pseudovirus that expresses the key surface Spike protein, which mediates its entry into cells.

This Notice announces the availability of administrative supplements for investigators and institutions funded through:

  • The NIH Microphysiological Systems (MPS) Program; or
  • SBIR/STTR-supported investigators, provided the award involves tissue chips; or
  • Microphysiological systems programs from across NIH.

Applications will be accepted on a rolling basis from May 15, 2020 through January 25, 2022.

Agency Website

Amount Description


    Funding Type





    Engineering and Physical Sciences
    Medical - Basic Science
    Medical - Clinical Science
    Medical - Translational

    External Deadline

    January 25, 2022