NIGMS is issuing this Notice of Special Interest (NOSI) to highlight the urgent need for research on SARS-CoV-2 and Coronavirus Disease 2019 (COVID-19).

NIGMS will accept the submission of applications for Competitive Revisions to active grants to address only the following research areas of interest:

• Incorporation of data related to SARS-CoV-2 into ongoing research efforts to develop predictive models for the spread of SARS-CoV-2 and other related infectious agents (all relevant grants).

• Repurposing or modification of diagnostic tools currently under development to enable rapid detection of SARS-CoV-2 infection (SBIR/STTR grants only).

• Rapid development of potential therapeutic agents for COVID-19 (SBIR/STTR only).

Applications that are not responsive to the above research areas of interest will be withdrawn without review.

Applications in response to this NOSI must be submitted to PA-18-935 "Urgent Competitive Revision to Existing NIH Grants and Cooperative Agreements (Urgent Supplement - Clinical Trial Optional)", which is intended to provide funds for NIH grantees applying to expand the scope of their active grant. The activity code will be the same as that of the parent award.

Competitive revision applications to PA-18-935 must use the application form package with the Competition ID of “NOT-GM-20-025-FORMS-E." This FOA will be reissued with a “NOT-GM-20-025-FORMS-F” package on May 25, 2020. Submissions to PA-18-935 must be completed by June 25, 2020. Submissions to the reissued FOA will be accepted on or after May 25, 2020 through the expiration date of this Notice.

Applications will be accepted on a rolling basis from March 25, 2020 to February 5, 2021 by 5:00 PM local time of the applicant organization. This NOSI expires on February 6, 2021 . An application submitted in response to this NOSI that is received on/after the expiration date will be withdrawn.