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Posted: 6/6/2025

Notice of Special Interest (NOSI): Synthetic Biology for Biomedical Applications

The purpose of this Notice of Special Interest (NOSI) is to announce that the National Center for Complementary and Integrative Health (NCCIH), the National Cancer Institute (NCI), the National Heart, Lung and Blood Institute (NHLBI), the National Institute on Aging (NIA), the National Institute of Allergy and Infectious Diseases (NIAID), the National Institute of Biomedical Imaging and Bioengineering (NIBIB), the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), and the National Institute of General Medical Sciences (NIGMS) are encouraging new applications to advance research activities relevant to synthetic biology.

The overarching goal(s) of this Notice of Special Interest are to:

  1. Develop tools and technologies to control and reprogram biological systems
  2. Apply synthetic biology approaches for the development of biomedical technologies
  3. Increase the fundamental understanding of synthetic biology concepts as they relate to human health
  4. Gain fundamental biological knowledge through the application of synthetic biology approaches

This notice applies to due dates on or after May 16, 2023 and subsequent receipt dates through May 17, 2026.

NOT-EB-23-002