Novel Methods for Obtaining Molecular Information from Archived Tissue Samples (R43/R44)

Funding Agency:
National Institutes of Health

This Funding Opportunity Announcement (FOA) solicits Small Business Innovative Research (SBIR) grant applications from small business concerns (SBCs) to develop novel technologies to expand the capability for molecular analyses of banked frozen or formalin-fixed, paraffin-embedded tissues. There is a need for improved tissue preservation methods that maintain histologic features while preserving high quality DNA, RNA, protein and small molecules in archived tissue from rodent and human studies. In addition, novel approaches are needed to preserve DNA, RNA, and small molecules during collection and storage of biological samples.  


  • Letter of Intent Due Date(s): November 5, 2016  
  • Application Due Date(s): December 5, 2016

RFA-ES-16-012 Expiration Date December 6, 2016

Agency Website

Eligibility Requirements

Only United States small business concerns (SBCs) are eligible to submit applications for this opportunity.



Amount Description

According to statutory guidelines, total funding support (direct costs, indirect costs, fee) normally may not exceed $150,000 for Phase I awards and $1,000,000 for Phase II awards. 

Funding Type





Medical - Basic Science
Medical - Clinical Science
Medical - Translational

External Deadline

December 5, 2016