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Nutrition for Precision Health, powered by the All of Us Research Program: Artificial Intelligence for Multimodal Data Modeling and Bioinformatics Center (U54 Clinical Trial Not Allowed)
The purpose of this FOA is to invite applications for the Artificial Intelligence for Multimodal Data Modeling and Bioinformatics (AIMDMB) Center to join the Nutrition for Precision Health consortium (https://commonfund.nih.gov/nutritionforprecisionhealth). Awards made through this FOA will generate actively learning algorithms to predict human response to different foods, nutrients, food components, and dietary patterns as well as advance understanding, from the individual and population level, of longitudinal dynamics from multimodal data with advanced computer modeling tools (e.g., with in silico human dietary response replicates or user-tailored, high-fidelity models that incorporate demographic, environmental, behavioral, multi-omic, social, cultural, clinical or other data to predict health trajectories).The Center will support the development of robust and artificially intelligent informatics platforms of multimodal, metadata-complete, human data sets from the Nutrition for Precision Health consortium. The proposed Center projects will develop a suite of computational tools to perform data integration, harmonization, analysis and visualization of the multi-modal and multi-fidelity data as well as incorporate an adaptive design for future data incorporation. The proposed Center will be a hub in communicating state of the art for ‘AI-ready' biomedical data to the Nutrition for Precision Health consortium. All Nutrition for Precision Health awardees must work collaboratively to plan and execute a large dietary intervention study to catalyze precision nutrition research in transforming the application of targeted dietary approaches to improve health and reduce chronic diseases. The end products of the Nutrition for Precision Health consortium will be a rich data resource for research use and algorithms to improve the precision of nutrition advice for individuals. The consortium projects will be directly connected with the All of Us Research Program and will enroll existing All of Us participants. All Nutrition for Precision Health data will be shared via the All of Us Researcher Workbench. The All of Us Research Program is guided by a set of core values that will also guide the Nutrition for Precision Health consortium.
- Letter of Intent: 30 days prior to the application due date
- Application: April 6, 2021
RFA-RM-21-001 Expiration Date April 7, 2021
Areas of Interest
Companion FOAs of the Nutrition for Precision Health Consortium
The set of six companion FOAs and existing All of Us Research Program components will establish the Nutrition for Precision Health consortium.
- RFA-RM-21-002: Nutrition for Precision Health, powered by the All of Us Research Program: Metabolomics and Clinical Assay Center (U24 Clinical Trial Not Allowed). A Metabolomics and Clinical Assays Center will perform metabolomics analyses and other clinical assays on biospecimens.
- RFA-RM-21-003: Nutrition for Precision Health, powered by the All of Us Research Program: Microbiome and Metagenomics Center (U24 Clinical Trial Not Allowed). A Microbiome and Metagenomics Center will perform microbiome, metagenomics and metatranscriptomics analyses on stool samples for all participants.
- RFA-RM-21-004: Nutrition for Precision Health, powered by the All of Us Research Program: Dietary Assessment Center (U24 Clinical Trial Not Allowed). A Dietary Assessment Center will apply at least two innovative approaches to assess dietary intake in all participants, and improve these methodologies through validation, evaluation, and modeling efforts with data from free-living and controlled feeding studies.
- RFA-RM-21-005: Nutrition for Precision Health, powered by the All of Us Research Program: Clinical Centers (UG1 Clinical Trial Required). Clinical Centers will engage, consent, and enroll participants from All of Us and conduct 3 diet modules (usual dietary assessment, a controlled feeding dietary intervention and a domiciled dietary intervention).
- RFA-RM-21-006: Nutrition for Precision Health, powered by the All of Us Research Program: Research Coordinating Center (U24 Clinical Trial Not Allowed). The Overall study coordination and data management (this FOA) will be provided by a Research Coordinating Center (RCC).
In view of the goals for this FOA, applicants should assemble a multi-disciplinary team with expertise in biomedical data science, systems biology, artificial intelligence, and nutrition as well as other biological and physical science expertise, if viewed as necessary to facilitating a successful outcome when preparing the application and as outlined in Section I.
Any individual designated as a PD/PI must not be designated as a PD/PI on another AIMDMB Center application.
The NIH Common Fund intends to commit approximately $2,000,000 in FY2022 and FY2023, and $3,000,000 per year for FY2024 through FY2026. Approximately one award is anticipated, contingent upon availability of funds and receipt of a sufficient number of meritorious applications.