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Patient-Partnered Collaborations for Single-Cell Analysis of Rare Inflammatory Pediatric Disease
The Chan Zuckerberg Initiative invites applications from collaborative teams bringing together patient-led rare disease organizations and research teams for 4-year research projects aimed at advancing our understanding of the fundamental science of rare diseases. The Patient-Partnered Collaborations for Single-Cell Analysis of Rare Inflammatory Pediatric Disease RFA aims to support the application of single-cell biology methods to rare inflammatory pediatric diseases that will clarify cellular mechanisms of disease, understand disease heterogeneity, and improve biomarker identification or diagnostics.
Awards are $2,000,000 USD total costs for four years for each project (distributed amongst research institutions and a patient organization). The award period for each RFA is an initial two years of funding, followed by an additional two years, pending evaluation. Applicants are welcome to apply to both this opportunity and the Patient-Partnered Collaborations for Rare Neurodegenerative Disease RFA; however, the application and scope of work must be distinct.
Deadline: May 24, 2022
Applications should be submitted by the Coordinating PI at a research institution as described below. Patient organizations and the Lead Patient Organization PI must be included in project conception, execution, and analysis as detailed by the application submitted by the Coordinating PI. If selected for funding, research funds will be disbursed separately to 1) the research institution of the Coordinating PI, who will be responsible for distributing funds as appropriate to support the work of co-PIs in the same or other research institutions, and 2) to the patient organization. Applicants may submit only ONE application to this RFA. Applicants are welcome to apply to both this opportunity and the opportunity titled “Patient-Partnered Collaborations (PPC) for Rare Neurodegenerative Disease”; however, the application and scope of work must be distinct.
- Applications may be submitted by domestic and foreign nonprofit organizations, public and private institutions, such as colleges, universities, hospitals, laboratories, units of state and local government, and eligible agencies of the federal government. For-profit organizations are not eligible to receive funding but may be involved in projects as a collaborator. All grants will be awarded to institutions, not individuals.
- Research institutions may be based in any country.
- More than one application will be accepted from each research institution.
- Each Coordinating PI and patient organization may only submit one application to this RFA.
- Each application should designate one Principal Investigator (PI) as the Coordinating Principal Investigator (Coordinating PI). The Coordinating PI will act as the administrative contact between CZI and all other PIs on the grant (co-PIs). The Coordinating PI must submit the application on behalf of all PIs. The Coordinating PI must be affiliated with the institution submitting the application, and grant funds will be awarded to that institution, which will take responsibility for distributing funds to all other research institutions. Note that institutions outside the U.S. may not subcontract to U.S. institutions, so please be mindful when selecting the Coordinating PI/institution.
- Principal Investigators may only serve as funded Principal Investigators on one application. They can be involved in multiple applications as unfunded collaborators, but should not be named as Coordinating PIs or co-PIs on multiple applications.