Pediatric Cancer Research- Immunology or Immunotherapy

Funding Agency:
V Foundation

The V Foundation is pleased to announce a new grant opportunity in pediatric cancer immunology or pediatric cancer immunotherapy. Advances in cancer immunology research have led to recent unprecedented successes of immunotherapy in the clinic. We are seeking proposals that will further advance knowledge on the mechanisms driving anti-cancer immunity, including work on tumor antigens, immune biomarkers and the tumor immune microenvironment which may have future translational value.

We welcome proposals of preclinical research/translational research that supports new approaches to immunotherapy and immune-prevention of cancer, specifically in pediatric cancer research. We are interested in various immunotherapy/ cancer immunology research questions as applied to pediatric cancer, including: biomarker research for stratification, biomarker validation research, combination of checkpoint inhibitors with vaccines. We encourage cross disciplinary research, including expertise from other disciplines (for example: bioinformatics, computational scientists, or engineers) as applicable to the research. Grants will be awarded through the Translational Award grant mechanism.

Translational projects should move a novel strategy from the laboratory into a human clinical trial or use specimens from a clinical trial to develop biomarkers or mechanisms. The research should apply in some direct way to human beings within the time frame of less than 5 years. If biomarker research is undertaken, a validation set or independent clinical trial is essential. A plan for biomarker validation, if applicable, must be included in any proposal. The endpoint of the project should be the planning or initiation of a new clinical trial. The Award is a three-year grant of $200,000 per year. A maximum of 10% indirect costs (within the award amount) are supported in the Award. NIH salary caps are observed

  • Duke Internal Deadline: May 22, 2017
  • LOI Deadline: June 2, 2017
  • Full Application: July 15, 2017

Eligibility Requirements

  • Grant applicants must be nominated by their Cancer Center Director or designee (see below).
  • Nominated applicants who will lead the research team must meet all of the following criteria to be eligible to submit an application:
  • The nominee must be nominated by their Cancer Center Director if the research institution is a cancer center. If the research institution is not a cancer center, then the provost, dean or other senior research administrative official who is responsible for the internal nominee selection process may make the nomination. Please do not share this invitation outside of your institution. We do not review unsolicited applications and will only accept one nominee per invited institution.
  • Applicant must be employed at a US non-profit research institution (e.g. 501c3, Section 170).
  • By the Due Date of the Application, applicants who will lead this research team must have all the following:
    • Be scientists who hold a faculty position at their cancer research institution. Non-promotable, adjunct, affiliated, temporary, part-time or acting faculty positions are not eligible for Principal Investigator nomination to lead the Translational Research Team.
  • Applicants must be either US Citizens or have a legal permit to work in the USA (either temporary or permanent).

Funding Type

Grant

Category

Medical
Medical - Basic Science
Medical - Clinical Science
Medical - Translational

Internal Nomination

The following items are required and will be reviewed by the DCI’s Scientific Review Committee.

  1. Applicant’s NIH Biosketch
  2. Two (2) page summary including the following information:
  • Title of the proposed research project
  • Brief description of the research proposal
  • Brief statement of applicant’s eligibility

Please note that the selected nominee(s) will be asked to fill out a Letter of Intent (LOI) which will be submitted to the V Foundation along with the nominees nomination form.  Additional details will be provided to the selected nominee.

Applications for internal review are due to Erin Carr (erin.carr@duke.edu) no later than Monday, May 22nd   (please send your application in one PDF).  Selected nominees will be notified by Friday, May 26th.

 

 

Internal Deadline

May 22, 2017

External Deadline

June 2, 2017