Phased Large Awards for Comparative Effectiveness Research (PLACER) -- Cycle 1 2024

Funding Agency:
Patient-Centered Outcomes Research Institute

The Patient-Centered Outcomes Research Institute (PCORI) intends to release a Phased Large Awards for Comparative Effectiveness Research (PLACER) PCORI Funding Announcement (PFA) on January 9, 2024, seeking to fund high-quality patient-centered comparative clinical effectiveness research (CER) projects that will address critical decisions faced by patients, families, caregivers, clinicians, and the health and healthcare community and for which there is insufficient evidence. This preannouncement is provided to allow potential applicants additional time to identify collaborators; obtain patient, community and stakeholder input on potential studies; and create responsive, high-quality proposals.  

Investigators must propose an individual-level or cluster randomized controlled trial of significant scale and scope for this PFA. The proposed trials should address critical decisional dilemmas that require important new evidence about the comparative clinical effectiveness of available interventions. Proposed studies should compare interventions that already have robust evidence of efficacy and are in current use. If efficacy is not well established, then widespread use must be documented. Clinical interventions (such as medications, diagnostic tests or procedures) and delivery system interventions (such as workforce, technologies and healthcare service delivery designs) are appropriate for these studies.  

This funding announcement anticipates that proposed research projects will require two phases of funding. The initial phase of funding supports a distinct feasibility phase intended for purposes of study refinement, infrastructure establishment, patient and stakeholder engagement, and feasibility testing of study operations, including the ability to recruit and enroll participants successfully. Using the feasibility phase to establish evidence of an intervention’s efficacy or effect size is not permitted. Approval to proceed to the second phase will be contingent on achieving specific milestones and deliverables established for the feasibility phase.     

Letter of Intent (LOI) Deadline: Feb. 6, 2024

Agency Website

Areas of Interest

This funding opportunity seeks applications addressing any of the three National Priorities for Health listed below. To be considered responsive, applications must propose research meeting the distinctive requirements of this PFA and address at least one of the following National Priorities for Health: 

  • Increase Evidence for Existing Interventions and Emerging Innovations in Health  

    • Goal: Strengthen and expand ongoing comparative clinical effectiveness research focused on both existing interventions and emerging innovations to improve healthcare practice, health outcomes and health equity.  

  • Achieve Health Equity  

    • Goal: Expand stakeholder engagement, research and dissemination approaches that lead to continued progress toward achieving health equity in the United States.  

  • Accelerate Progress Toward an Integrated Learning Health System  

    • Goal: Foster actionable, timely, place-based and transformative improvements in patient-centered experiences, care provision and ultimately improved health outcomes through collaborative, multisectoral research to support a health system that understands and serves the needs and preferences of individuals.  

Funding Type

Grant

Eligibility

Faculty

Category

Community Outreach and Engagement
Medical
Medical - Clinical Science
Social Sciences

External Deadline

February 6, 2024