Phenotypic and Functional Characterization of ApoE2 to Inform Translation Strategies for Aging-Related Conditions (R01, R21)

Funding Agency:
National Institutes of Health

The purpose of this FOA is to conduct basic and translational studies on ApoE2 and other variants to improve understanding of physiologic and cellular differences attributable to the ApoE e2 allele (vs. other ApoE alleles), and how they mediate ApoE e2’s differential effects on longevity and risk for age-related conditions.  This will aid in the identification of potential therapeutic targets for interventions that prevent or ameliorate aging-related diseases by mimicking favorable differential effects of the ApoE e2 variant, while avoiding adverse effects.  

Although this funding opportunity uses the R01 grant mechanism, it runs in parallel with a program announcement of identical scientific scope, PAR-16-371, which uses the exploratory/developmental (R21) grant mechanism.


  • R01 Due Dates: Feb. 5, Jun. 5, Oct. 5
  • R21 Due Dates: Feb. 16, Jun. 16, Oct. 16

PAR-16-370 Expiration Date September 8, 2019




Medical - Basic Science
Medical - Translational

External Deadline

June 5, 2019