The purpose of this FOA is to conduct basic and translational studies on ApoE2 and other variants to improve understanding of physiologic and cellular differences attributable to the ApoE e2 allele (vs. other ApoE alleles), and how they mediate ApoE e2’s differential effects on longevity and risk for age-related conditions. This will aid in the identification of potential therapeutic targets for interventions that prevent or ameliorate aging-related diseases by mimicking favorable differential effects of the ApoE e2 variant, while avoiding adverse effects.
Although this funding opportunity uses the R01 grant mechanism, it runs in parallel with a program announcement of identical scientific scope, PAR-16-371, which uses the exploratory/developmental (R21) grant mechanism.
Deadlines:
PAR-16-370 Expiration Date September 8, 2019
