Pilot and Feasibility Clinical and Translational Research Studies in Digestive Diseases and Nutrition (R21 Clinical Trial Optional)

Funding Agency:
National Institutes of Health

The purpose of this Funding Opportunity Announcement is to foster the advancement of the research mission of the Division of Digestive Diseases and Nutrition, NIDDK by invitingresearch concepts for clinical pilot and feasibility research studies; and translational research studies in digestive diseases and nutrition.  Specifically, this FOA is invitingtwo types of studies: Clinical Pilot and Feasibility study proposals; and Clinical Translational Science proposals that will promote exploratory and novel science through the use of human subjects biospecimens.  The following studies will not be supported by this FOA: those that have obesity as a component of the study proposal (please refer to the Office of Extramural Research Grants and Funding to search for multiple obesity related Funding Opportunity Announcements at https://grants.nih.gov/grants/oer.htm); and translational studies that utilize animal models.


  • R21 Due Date: Feb. 16, Jun. 16, Oct. 16
  • AIDS Due Dates: Jan. 7, May 7, Sep. 7

PA-18-903 Expiration Date: September 8, 2021

Agency Website



Amount Description

Direct costs are limited to $275,000 over an R21 two-year period, with no more than $200,000 in direct costs exclusive of any consortium F&A costs allowed in any single year.

Funding Type





Medical - Clinical Science
Medical - Translational

External Deadline

June 16, 2021