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Pilot Clinical Trials in Pediatric Chronic Kidney Disease Data Coordinating Center (U24)
The purpose of this Funding Opportunity Announcement (FOA) is to initiate and implement a network of participating clinical centers and a data coordinating center to perform pilot and feasibility studies of therapies to slow or reverse the progression of chronic kidney disease (CKD) in children. This FOA invites applications for the Data Coordinating Center (DCC) and runs in parallel with a separate FOA that invites applications for the Participating Clinical Centers (PCCs) (RFA-DK-16-018). These pilot studies will seek to optimize critical elements of a full-scale randomized control trial design - the most promising study question, agent(s), target population, dosing, data collection, and appropriate outcomes. Applicants must propose two trial designs to be conducted sequentially over the funding period. One trial will be to lower serum uric acid levels, while the other can be an appropriately justified study question of the applicant's choosing. The ultimate goal of this FOA is to obtain the necessary information to design and implement one or more full-scale randomized controlled clinical trial of therapies to reduce morbidity in children with CKD.
- Letter of Intent Due Date(s): January 17, 2017
- Application Due Date(s): February 17, 2017
RFA-DK-16-035 Expiration Date February 18, 2017
An applicant may request a budget for direct costs up to $350,000/year.
The maximum project period is five years.