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Post-Stroke Vascular Contributions to Cognitive Impairment and Dementia (VCID) in the United States Including in Health Disparities Populations (U19 Clinical Trial Not Allowed)
With one in three people having a clinical stroke during their lifetime and dementia occurring in an estimated 30% of post-stroke patients, the public health impact is enormous. The purpose of this FOA is to determine the specific subsets of stroke events that cause (and do not cause) cognitive impairment and dementia in post-stroke populations in the United States, including in health disparities populations, and what additional clinical factors, as well as comorbidities including those along the AD/ADRD spectrum, may causally synergize with stroke to result in cognitive impairment and dementia outcomes. Applicants are encouraged to leverage existing resources for VCID, stroke and other dementia research.
Applications are requested for one large prospective clinical research study to determine associations between stroke subtypes, the clinical context in which they occur, and subsequent development of cognitive impairment, including dementia. The overarching goal of this research program is to determine the specific subsets of stroke events that cause (and do not cause) cognitive impairment and dementia in post-stroke populations in the United States and what additional clinical factors and comorbidities may causally synergize with stroke to result in or prevent cognitive impairment and dementia outcomes. The study must be sufficiently powered to answer these questions in typical US populations, including in at least two health disparities populations proposed in the application, that are representative of gender, racial, and ethnic diversity in the United States.
- Letter of Intent Due Date(s): March 4, 2019
- Application Due Date(s): April 17, 2019
RFA-NS-19-012 Expiration Date April 18, 2019
Budgets are limited to $39,000,000 in Direct Cost over the total project period.
The scope of the proposed project should determine the project period. The maximum project period is 6 years.