Postbaccalaureate Research Education Program (R25 - Independent Clinical Trial Not Allowed)

Funding Agency:
National Institutes of Health

The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH.  The over-arching goal of this R25 program is to support educational activities that encourage individuals from diverse backgrounds, including those from groups underrepresented in the biomedical and behavioral sciences, to pursue further studies or careers in research 

To accomplish the stated over-arching goal, this FOA will support creative educational activities with a primary focus on:

  • Courses for Skills Development
  • Research Experiences

This funding opportunity announcement (FOA) provides support to eligible, domestic institutions to develop and implement effective, evidence-informed approaches to biomedical research education and mentoring that will keep pace with the rapid evolution of the research enterprise. NIGMS expects that the proposed research education programs will incorporate extensive research experiences and well-designed courses for skills development to prepare recent baccalaureates from diverse backgrounds to transition into and complete rigorous, research-focused doctoral degree programs (e.g., Ph.D. or M.D./Ph.D.) in biomedical fields. This program is limited to applications from doctoral degree-granting institutions that are research-intensive (i.e., those with NIH research project grant (RPG) funding averaging greater than or equal to $7.5 million in total costs per year over the last three fiscal years).

This Funding Opportunity Announcement (FOA) does not allow appointed participants to lead an independent clinical trial but does allow them to obtain research experience in a clinical trial led by a mentor or co-mentor.

Only one application per institution is allowed.


  • Duke Internal Deadline: Sep. 25, 2020
  • Application Due Date(s): February 21, 2020; January 27, 2021; January 27, 2022​

PAR-20-066 Expiration Date: January 28, 2022

Agency Website

Eligibility Requirements

For research education and training programs to enhance diversity, NIGMS recognizes separate institutional eligibility tracks: research-intensive, i.e., those with NIH research project grant (RPG) funding averaging greater than or equal to $7.5 million in total costs (direct and F&A/indirect) per year over the last three fiscal years; and research-active, i.e., those with NIH research project grant (RPG) funding averaging less than $7.5 million in total costs per year over the last three fiscal years (RPG data are available through NIH RePORT). For example, FY 2017, FY 2018 and FY 2019 for applications submitted in January 2020.

Institutional eligibility for this FOA is limited to research-intensive institutions (as defined above) that have strong biomedical Ph.D. degree programs in NIGMS mission areas. That is, institutions that are eligible for MARC or IMSD are eligible to apply, but those that are eligible for U-RISE or G-RISE are not eligible. Further, NIGMS encourages applications from highly research-intensive institutions (i.e., those with an average of NIH funding greater than or equal to $20 million total costs per year over the last three fiscal years) that have a significant number of faculty mentors with active and extramurally funded research programs (e.g., R01, R35 or equivalent awards) and robust research education environments.

An institution (normally identified by having a unique DUNS number or NIH IPF number) can have no more than one PREP award.

The sponsoring institution must assure support for the proposed program through an “Institutional Support Letter” within the “Letters of Support” attachment. Appropriate institutional commitment to the program includes the provision of adequate staff, facilities, and educational resources that can contribute to the planned program. Additionally, a signed letter is required from the Authorized Organization Representative/Business Official or similar official with institution-wide responsibility verifying the eligibility of the applicant institution at the time of application submission according to the eligibility criteria indicated above. See the application instructions for the required “Letters of Support” attachment in Section IV.2.

Institutions with existing Ruth L. Kirschstein National Research Service Award (NRSA) institutional training grants (e.g., T32) or other Federally funded training programs may apply for a research education grant provided that the proposed educational experiences are distinct from those training programs receiving federal support. In many cases, it is anticipated that the proposed research education program will complement ongoing research training occurring at the applicant institution.

As described in the instructions for the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) in Section IV.2 below, NIGMS encourages multiple PD(s)/PI(s), particularly when each brings a unique perspective and skill set that will enhance the research education program. The PD(s)/PI(s) must be able to provide both administrative and scientific leadership to the development and implementation of the proposed program. At least one of the PD(s)/PI(s) should be an established investigator in the biomedical sciences. Additional PD(s)/PI(s), including individuals with experience in the science of education, relevant social science disciplines, program evaluation, mentoring, and university administration may be included to achieve the program goals. Any of the PD(s)/PI(s) may serve as the contact PD/PI. The contact PD/PI is expected to have a full-time appointment at the applicant institution unless extremely well-justified. If the full-time status of the contact PD/PI changes after the award, the institution must obtain prior program approval to appoint a new PD/PI or request a deviation from the full-time rule. The PD(s)/PI(s) will be responsible for the selection and appointment of participants to the approved research education program, and for the overall direction, management, administration, and evaluation of the program. The PD(s)/PI(s) will be expected to monitor and assess the program and submit all documents and reports as required. The PD(s)/PI(s) have responsibility for the day-to-day administration of the program and are responsible for appointing members of the Advisory Committee (when applicable) and using their recommendations to determine the appropriate allotment of funds.





    Amount Description

    The total direct costs for each award are limited to $400,000 annually.

    The total project period may not exceed 5 years.

    Funding Type





    Curriculum Development
    Engineering and Physical Sciences
    Environmental & Life Sciences
    Medical - Basic Science
    Medical - Clinical Science
    Medical - Translational
    Social Sciences

    Internal Nomination

    Owing to the sponsor's restriction on the number of applications that may be submitted from Duke, anyone wishing to pursue nomination should submit the following materials as one PDF.

    • NIH Biosketch
    • NIH Specific Aims (1 page)

    Please submit internal materials through My Research Proposal. (Code ILN)

    Instructions for setting up your account and uploading internal applications can be found here:


    Internal Deadline

    September 25, 2020

    External Deadline

    January 27, 2021