Prevention Grants (2022)

Funding Agency:
Amyotrophic Lateral Sclerosis Association

One of the ALS Association’s goals is to prevent or delay the onset of ALS. Specifically, by 2030, at the latest, when someone is diagnosed with ALS, we would like to be able to offer some advice for their families on how to reduce their risk of developing ALS. Achieving this ambitious goal requires a large body of knowledge, including an understanding of the causes and risk factors for ALS, methods for predicting when the clinical manifestations of ALS will emerge, and viable strategies to intervene either by mitigating risk or by treating the underlying biology of disease before clinically manifest ALS emerges. This 2030 timeframe guides us to emphasize validation and translation rather than exploratory studies. These 2-year awards with a maximum budget of $400,000 seek to advance the translational science, interventions and tools that could eventually prevent or delay the onset of ALS.

Letter of Intent due August 25, 2022

Agency Website

Eligibility Requirements

• Individuals with the skills, knowledge, and resources necessary to carry out the proposed research may apply as a principal investigator

• Individuals do not need to have a scientific background in ALS research

• Senior post-doctoral fellows, defined as fellows who will have been in their current postdoctoral position for at least three years on the date full proposals are due, may apply as a principal investigator (Letter of Collaboration from mentor will be required at the Full Proposal stage) o Junior post-doctoral fellows are not eligible to apply to this opportunity but are invited to consider The ALS Association’s Milton Safenowitz Postdoctoral Fellowship instead

• Established investigators, early career investigators and investigators from outside the field of ALS are all eligible to apply as a principal investigator 



Amount Description

  • The maximum period of performance is two years
  • The maximum total budget is $400,000 (inclusive of both direct and indirect costs)
  • Indirect costs are limited to 10 percent of the total direct costs   
  • All funds must be expended within the approved period of performance

Funding Type



Junior Faculty
Post Doctoral Fellows


Medical - Basic Science
Medical - Clinical Science
Medical - Translational

External Deadline

August 25, 2022