Prevention Grants (2023)

Funding Agency:
Amyotrophic Lateral Sclerosis Association

The ALS Association’s Prevention Grants support efforts to prevent or delay the harms of ALS, emphasizing validation and translation over discovery. 

Prevention Grants provide up to $400,000 over 2 years to help advance translational science, interventions, and tools that could eventually prevent or delay the onset of ALS. Projects that will likely lead to human impact within the next 5–7 years will be given preference over longer term research.  

Letter of Intent due May 17, 2023

Agency Website

Areas of Interest

For this funding opportunity, we will accept applications from all scientific disciplines on topics that have the potential to ultimately prevent ALS. In addition to projects focused on ALS, projects that investigate the continuum of disease spanning ALS and frontotemporal dementia (FTD) are in scope. 

We are especially interested in:  

  • Improved tools for demonstrating a causative role of environmental exposures in a scientifically rigorous manner that is less burdensome to people with ALS. 
  • Development of frameworks for determining the level of evidence required to translate knowledge of an environmental risk factor into a pharmaceutical, behavioral, or ecological intervention. 
  • Preclinical or clinical drug development aimed at preventing ALS, including efforts to treat prodromal syndromes such as mild motor impairment (MMI). 
  • Partnerships across FTD and other neurodegenerative and neuropsychiatric disease communities to mitigate ALS risk among different elevated-risk populations. 
  • New studies leveraging existing population-based cohorts to study environmental risk factors for ALS as well as MMI as a clinical syndrome that is prodromal to ALS. 
  • Infrastructure to enable study of those at elevated risk for ALS, including clinical cohorts and efforts designed to study potential interactions between genetic and environmental risk factors. 
  • Any other proposal with the potential to prevent the onset of ALS. 

Please note: This funding opportunity will not support studies intended to identify new ALS-associated genes or new associations between ALS and environmental exposures. 

Eligibility Requirements

Individuals with the skills, knowledge, and resources necessary to carry out the proposed research may apply as a principal investigator. Individuals do not need to have a scientific background in ALS research. Established investigators, early career investigators, and investigators from outside the ALS field are all encouraged to apply. Junior postdoctoral fellows are not eligible to apply as principal investigators.  



Amount Description

Budgets for total costs up to $400,000 (inclusive of both direct and indirect costs) may be requested for a period of 2 years. Indirect costs are limited to 10% of total direct costs.  

Funding Type



Junior Faculty
Post Doctoral Fellows


Medical - Basic Science
Medical - Clinical Science
Medical - Translational

External Deadline

May 17, 2023