This Notice of Funding Opportunity (NOFO) invites applications that propose research focused on major toxicants observed to be associated with elevated Alzheimer's Disease (AD) and AD-related dementias (ADRD) risk, and health disparities in AD/ADRD-related pathologic and clinical outcomes. This NOFO aims to do the following:

1. Enrich existing longitudinal cohorts with measures of exposures to individual toxicants or combinations of toxicants and/or multi-omics molecular profiling that reflects the body’s response to exposure(s) 
2. Support the development of multi-disciplinary teams needed for the rigorous measurement and assessment of environmental exposures at the population level 
3. Create an environmental epidemiology consortium to facilitate rapid and broad data sharing, harmonization, and integration of complex exposure data across multiple studies to enhance the opportunity for data pooling and data integration for various meta-analyses and/or comparative analyses

This NOFO, in conjunction with its two companion NOFOs: RFA-AG-24-021 and RFA-AG-24-023, aims to establish a “Precision Environmental Health in AD/ADRD Tri-consortium” and lay the foundation for a precision environmental health approach to AD/ADRD risk reduction and disease prevention.

Deadlines:

• Letter of Intent Due Date(s): September 22, 2023

• Application Due Date: October 23, 2023

RFA-AG-24-022 Expiration Date October 24, 2023