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Rare Genetic Disorders as a Window into the Genetic Architecture of Mental Disorders (Collaborative U01 Clinical Trial Not Allowed)
This initiative will foster collaborative and coordinated efforts to characterize the underlying genetic architecture of diverse neuropsychiatric phenotypes within and across rare genetic disorders and identify the shared genetic risk across rare and idiopathic neuropsychiatric disorders. Projects from multi-disciplinary teams will utilize genome-wide data to comprehensively assess the contribution of genetic variation to the variable expressivity and incomplete penetrance of neuropsychiatric phenotypes across rare genetic disorders. Projects are encouraged to leverage existing resources, cohorts, and collaborative networks with established infrastructure for consistent and high-quality phenotypic data collection and genomic data generation. Projects should seek to enhance the quality of the phenotypic data available for rare genetic disorders by developing or applying phenotyping methodologies that create a pipeline for standardizing assessments and that cut across rare genetic disorders and across developmental time points. Under this initiative, investigators will form a network to facilitate data sharing and harmonization of clinical and genetic data across different studies within the network, as well as accelerate characterization of genotype to phenotype relationships across rare genetic disorders. This network will also generate a resource of bio-samples, as well as phenotypic and genetic data for broader dissemination to the scientific community.
This FOA should be used when two or more collaborating sites are essential to conduct the proposed research. It is required that the Research Strategy be identical across linked collaborative U01 applications, with the exception of a short section describing the specific function of each application under "elements unique to this site." The Human Subjects section for each application should be specific to the research conducted at that site. For a linked set of collaborative U01 applications, each application must have its own Program Director/Principal Investigator (PD/PI) and the program must provide a mechanism for cross-site coordination. Applications from a single-site should be submitted under the companion FOA (RFA-MH-19-200).
All awards supported under this FOA and the companion collaborative U01 FOA (RFA-MH-19-200) will be governed by the Mental Health Rare Genetic Disease Network (MHRGDN).
- Letter of Intent: 30 days prior to the application due date
- Application Due Date(s): August 9, 2018
RFA-MH-19-201 Expiration Date August 10, 2018
NIMH and NICHD intend to commit a total of at least $4,500,000 in FY 2019 to fund a total of 3-5 applications under this FOA and the companion FOA (RFA-MH-19-200). The total amount awarded and the number of awards will depend upon the quality, duration, costs and the receipt of a sufficient number of meritorious applications.