Reimagining Protein Manufacturing (RPM)

Funding Agency:
Defense Advanced Research Projects Agency

– The Reimagining Protein Manufacturing (RPM) program aims to ensure timely Department of Defense (DoD) access to critical medical countermeasures (MCMs) by establishing the foundational technologies needed for fully distributed, on-demand manufacturing of protein-based MCMs and associated raw materials. To achieve this goal, RPM will develop technologies to enable immediate synthesis (lead time approximately 24 hours) of bioactive protein MCMs and raw material production enzymes at a yield corresponding to ≥ 500 doses per week. This technology will allow the DoD to rapidly secure access to both therapeutic proteins and enzymes needed for nucleic acid-based MCM synthesis, and reduce reliance on complex supply chains.


o Proposal Abstract Due Date and Time: September 23, 2021, 4:00 PM ET

o Full Proposal Due Date and Time: November 16, 2021, 4:00 PM ET

Agency Website

Areas of Interest

  • Technical Area 1 (TA1): Production Yield and Time. Protein synthesis technologies for near-immediate synthesis of proteins at high yields.
  • Technical Area 2 (TA2): Post-Translational Modifications. Protein production approaches to add PTMs in a controlled manner to ensure the final product is bioactive and of high quality.

Funding Type





Engineering and Physical Sciences
Environmental & Life Sciences

External Deadline

November 16, 2021